Vitamin D deficiency is associated with the presence and severity of diabetic retinopathy in type 2 Diabetes Mellitus

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dc.contributor.authorAlcubierre Calvo, Núria
dc.contributor.authorValls Marsal, Joan
dc.contributor.authorRubinat, Esther
dc.contributor.authorCao, Gonzalo
dc.contributor.authorEsquerda, Aureli
dc.contributor.authorTraveset Maeso, Alicia
dc.contributor.authorGranado Casas, Minerva
dc.contributor.authorJurjo Campo, Carmen
dc.contributor.authorMauricio Puente, Dídac
dc.date.accessioned2015-09-14T11:07:16Z
dc.date.available2015-09-14T11:07:16Z
dc.date.issued2015
dc.description.abstractThere is very few evidences on the role of vitamin D in the development of diabetic retinopathy. The aim of the current study was to explore whether there is an association of vitamin D status and diabetic retinopathy in type 2 diabetes. Two groups of patients were selected: 139 and 144 patients with and without retinopathy, respectively, as assessed by an experienced ophthalmologist. Subjects with advanced late diabetic complications were excluded to avoid confounding biases. 25-Hydroxy-vitamin D3 (25(OH)D) concentrations and vitamin D deficiency were associated with the presence of diabetic retinopathy. Additionally, patients with more advanced stages of retinopathy (grades 2<br>4) had lower concentrations of 25(OH)D and were more frequently vitamin D deficient as compared with patients not carrying this eye complication. In conclusion, our study confirms the association of vitamin D deficiency with the presence and severity of diabetic retinopathy in type 2 diabetes. Further experimental and prospective studies on this issue are clearly warranted.
dc.description.sponsorshipThe authors are grateful to all staff members of the institutions involved in the study that contributed to the recruitment of participants and supported our activities. This study was supported by Grant PS09/01035 from Instituto de Salud Carlos III, Ministry of Economy and Competitiveness, Spain. Nuria Alcubierre holds a predoctoral fellowship also from Instituto de Salud Carlos III FI11/0008.
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2015/374178
dc.identifier.idgrec022805
dc.identifier.issn2314-6745
dc.identifier.urihttp://hdl.handle.net/10459.1/48699
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relationinfo:eu-repo/grantAgreement/MICINN//PS09%2F01035/ES/ESTUDIO EXPLORATORIO DE ORGANOS DIANA NO CLASICOS DE LA MICROANGIOPATIA DIABETICA/
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1155/2015/374178
dc.relation.ispartofJournal of Diabetes Research, 2015
dc.rightscc-by (c) Alcubierre Calvo, Núria et al., 2015
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.subject.classificationComplicacions de la diabetis
dc.subject.classificationMalalties de la retina
dc.subject.classificationVitamina D
dc.subject.otherDiabetes complications
dc.subject.otherRetinal diseases
dc.subject.otherVitamin D
dc.titleVitamin D deficiency is associated with the presence and severity of diabetic retinopathy in type 2 Diabetes Mellitus
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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