Developmental silencing and independency from E2F of apoptotic gene expression in postmitotic tissues
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Date
2007
Authors
Zhang, Jisheng
Bahi i Pla, Núria
Zubiaga, Ana M.
Comella i Carnicé, Joan Xavier
Llovera i Tomàs, Marta
Sanchis, Daniel
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Abstract
The involvement of caspases in postmitotic cell death
is controversial. Here we report that adult brain and heart are
devoid of many key pro-apoptotic proteins due to a progressive
postnatal silencing event involving a reduction of their transcript
levels. E2F has been shown to control cell cycle progression and
to be transcriptional activator of apoptotic genes. However, our
data demonstrate that apoptotic gene expression in heart, brain
and liver, as well as cardiac and neuronal apoptotic gene silencing
during development, are E2F-independent events. Therefore,
the genes regulating caspase-dependent cell death are expressed
in embryonic organs in an E2F-independent manner and a developmental-related
silencing event represses these genes in postmitotic
adult tissues.
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Journal or Serie
FEBS Letters, 2007, vol. 581, núm. 30, p. 5781-5786