Prevalence and Predictors of Cerebral Microangiopathy Determined by Pulsatility Index in an Asymptomatic Population From the ILERVAS Project

dc.contributor.authorPurroy Garcia, Francisco
dc.contributor.authorSánchez Peña, Enric
dc.contributor.authorLecube Torelló, Albert
dc.contributor.authorArque, Gloria
dc.contributor.authorVicente-Pascual, Mikel
dc.contributor.authorMauri-Capdevila, Gerard
dc.contributor.authorTorreguitart, Núria
dc.contributor.authorHernández García, Marta
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorFarràs-Sallés, Cristina
dc.contributor.authorMauricio Puente, Dídac
dc.contributor.authorBermúdez López, Marcelino
dc.description.abstractBackground: Little is known about the prevalence of cerebral microangiopathy (CM), which is related to cognitive impairment, in an asymptomatic population. Pulsatility index (PI) is an easily measurable parameter of cerebral vascular resistance in transcranial duplex of the middle cerebral artery (MCA) study. We aimed to determine the prevalence of CM measured by PI of MCA in low to moderate vascular risk subjects. Methods: We included 3,721 subjects between 45 and 70 years without previous history of vascular disease or diabetes mellitus and with at least one other vascular risk factor from the cross-sectional study ILERVAS (Lleida, Spain). Patients underwent transcranial duplex to determine MCA-PI. Possible CM was defined by MCA-PI >1.1. Carotid and femoral arteries ultrasound registration was done to determine the presence, the number, and the area of atheromatous plaques. Body mass index (BMI), pulse pressure (PP) and laboratory data were also recorded. Results: 439 (11.8%) subjects were excluded due to the low quality of transcranial duplex images. Median age was 57 [IQR 52, 62] years. Possible CM was found in 424 (12.9%) subjects. CM patients had higher prevalence of plaques than non-CM (77.4 vs. 66.4%, p < 0.001). PI showed a positive linear correlation with the number of territories with plaques (r = 0.130, p < 0.001), and the total plaque area (r = 0.082, p < 0.001). The predictors of possible CM were the age, male gender, and PP. Conclusions: In low-to-moderate vascular risk asymptomatic population, the proportion of abnormal brain microvascular bed determined by MCA-PI is not negligible. The planned 10-year follow-up will describe the clinical relevance of these findings.ca_ES
dc.description.sponsorshipThis work was supported by grants from the Diputacio de Lleida, Instituto de Salud Carlos III (RETIC RD16/0009/0011) and Ministerio de Ciencia, Inovación y Universidades (IJC2018-037792-I). FP was supported by the Catalan Autonomous Government’s Agència de Gestió d’Ajuts Universitaris i de Recerca (2017 suport a les activitats dels grups de recerca 1628). RP was supported by the Spanish Ministry of Science, Innovation, and Universities (grant RTI2018-099200-B-I00), and the Generalitat of Catalonia: Agency for Management of University and Research Grants (2017SGR696). This study was co-financed by FEDER funds from the European Union (A way to build Europe). IRBLleida is a CERCA Programme/Generalitat of Catalonia.ca_ES
dc.publisherFrontiers Mediaca_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099200-B-I00/ES/NEUROLIPIDOMICA DEL ENVEJECIMIENTO CEREBRAL HUMANO/ca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofFrontiers In Neurology, 2021, vol. 12ca_ES
dc.rightscc-by (c)Authors, 2021ca_ES
dc.subjectCerebral microangiopathyca_ES
dc.subjectExtracranial atheromatosisca_ES
dc.subjectPulsatility index (PI)ca_ES
dc.subjectTranscranial Doppler (TCD)ca_ES
dc.titlePrevalence and Predictors of Cerebral Microangiopathy Determined by Pulsatility Index in an Asymptomatic Population From the ILERVAS Projectca_ES
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
360.48 KB
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
1.71 KB
Item-specific license agreed upon to submission