Protective effect of intestinal helminthiasis against tuberculosis progression is abrogated by intermittent food deprivation
dc.contributor.author | Garrido Amaro, Cristina | |
dc.contributor.author | Cardona, Paula | |
dc.contributor.author | Gassó Garcia, Diana | |
dc.contributor.author | Arias, Lilibeth | |
dc.contributor.author | Velarde, Roser | |
dc.contributor.author | Tvarijonativiciute, Asta | |
dc.contributor.author | Serrano, Emmanuel | |
dc.contributor.author | Cardona, Pere-Joan | |
dc.date.accessioned | 2021-11-22T09:13:48Z | |
dc.date.available | 2021-11-22T09:13:48Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Background: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities. | ca_ES |
dc.description.sponsorship | The project leading to these results has received funding from la Caixa Foundation (ID 100010434), under agreement LCF/ PR/GN16/10290002. This work was supported by the Plan Nacional I + D + I co-financed by ISCIII-Subdirección General de Evaluación and Fondo-EU de Desarrollo Regional (FEDER) through PC contract IFI14/00015. LA was supported by the European Commission Horizon 2020 research and innovation program under grant agreement TBVAC2020 No. 64338. The Experimental Tuberculosis Unit is accredited by the Catalan Agency for Management of University and Research Grants (AGAUR) with code 2017 SGR500 and the IGTP is a member of the CERCA network of institutes. ES and AT are supported by the SpanishMinisterio de Ciencia Innovación y Universidades (MICINN) through a Ramon y Cajal agreements (RYC-2016-21120; RYC-2017-22992). The research activities of CG-A are supported by a research fellow linked to the RYC-2016-21120. | ca_ES |
dc.identifier.doi | https://doi.org/10.3389/fimmu.2021.627638 | |
dc.identifier.idgrec | 033889 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | http://hdl.handle.net/10459.1/72389 | |
dc.language.iso | eng | ca_ES |
dc.publisher | Frontiers Media | ca_ES |
dc.relation.isformatof | Reproducció del document publicat a https://doi.org/10.3389/fimmu.2021.627638 | ca_ES |
dc.relation.ispartof | Frontiers in Immunology, 2021, vol. 12, 627638 | ca_ES |
dc.relation.projectID | nfo:eu-repo/grantAgreement/EC/H2020/643381/TBVAC2020 | ca_ES |
dc.rights | cc-by (c) Garrido et al., 2021 | ca_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Co-infection | ca_ES |
dc.subject | Trichuris muris | ca_ES |
dc.subject | Heligmosomoides polygyrus | ca_ES |
dc.subject | Environmental mycobacteria Mycobacterium manresensis | ca_ES |
dc.subject | Tuberculosis | ca_ES |
dc.title | Protective effect of intestinal helminthiasis against tuberculosis progression is abrogated by intermittent food deprivation | ca_ES |
dc.type | info:eu-repo/semantics/article | ca_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_ES |