Protective effect of intestinal helminthiasis against tuberculosis progression is abrogated by intermittent food deprivation

dc.contributor.authorGarrido Amaro, Cristina
dc.contributor.authorCardona, Paula
dc.contributor.authorGassó Garcia, Diana
dc.contributor.authorArias, Lilibeth
dc.contributor.authorVelarde, Roser
dc.contributor.authorTvarijonativiciute, Asta
dc.contributor.authorSerrano, Emmanuel
dc.contributor.authorCardona, Pere-Joan
dc.date.accessioned2021-11-22T09:13:48Z
dc.date.available2021-11-22T09:13:48Z
dc.date.issued2021
dc.description.abstractBackground: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1β, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.ca_ES
dc.description.sponsorshipThe project leading to these results has received funding from la Caixa Foundation (ID 100010434), under agreement LCF/ PR/GN16/10290002. This work was supported by the Plan Nacional I + D + I co-financed by ISCIII-Subdirección General de Evaluación and Fondo-EU de Desarrollo Regional (FEDER) through PC contract IFI14/00015. LA was supported by the European Commission Horizon 2020 research and innovation program under grant agreement TBVAC2020 No. 64338. The Experimental Tuberculosis Unit is accredited by the Catalan Agency for Management of University and Research Grants (AGAUR) with code 2017 SGR500 and the IGTP is a member of the CERCA network of institutes. ES and AT are supported by the SpanishMinisterio de Ciencia Innovación y Universidades (MICINN) through a Ramon y Cajal agreements (RYC-2016-21120; RYC-2017-22992). The research activities of CG-A are supported by a research fellow linked to the RYC-2016-21120.ca_ES
dc.identifier.doihttps://doi.org/10.3389/fimmu.2021.627638
dc.identifier.idgrec033889
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/10459.1/72389
dc.language.isoengca_ES
dc.publisherFrontiers Mediaca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.3389/fimmu.2021.627638ca_ES
dc.relation.ispartofFrontiers in Immunology, 2021, vol. 12, 627638ca_ES
dc.relation.projectIDnfo:eu-repo/grantAgreement/EC/H2020/643381/TBVAC2020ca_ES
dc.rightscc-by (c) Garrido et al., 2021ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCo-infectionca_ES
dc.subjectTrichuris murisca_ES
dc.subjectHeligmosomoides polygyrusca_ES
dc.subjectEnvironmental mycobacteria Mycobacterium manresensisca_ES
dc.subjectTuberculosisca_ES
dc.titleProtective effect of intestinal helminthiasis against tuberculosis progression is abrogated by intermittent food deprivationca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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