Decoding viral and host microRNA signatures in airway-derived biosamples: Insights for biomarker discovery in viral respiratory infections

Simple item page
dc.contributor.authorMolinero, Marta
dc.contributor.authorPerez-Pons, Manel
dc.contributor.authorGonzález, Jessica
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorde Gonzalo Calvo, David
dc.date.accessioned2025-03-24T13:09:34Z
dc.date.available2025-03-24T13:09:34Z
dc.date.issued2024
dc.description.abstractThe global public health crisis caused by the COVID-19 pandemic has intensified the global concern regarding viral respiratory tract infections. Despite their considerable impact on health, society and the economy, effective management of these conditions remains a significant challenge. Integrating high-throughput analyses is pivotal for early detection, prognostication of adverse outcomes, elucidating pathogenetic pathways and developing therapeutic approaches. In recent years, microRNAs (miRNAs), a subset of small noncoding RNAs (ncRNAs), have emerged as promising tools for molecular phenotyping. Current evidence suggests that miRNAs could serve as innovative biological markers, aiding in informed medical decision-making. The cost-effective quantification of miRNAs in standardized samples using techniques routinely employed in clinical laboratories has become feasible. In this context, samples obtained from the airways represent a valuable source of information due to their direct exposure to the infectious agent and host response within the respiratory tract. This review explores viral and host miRNA profiling in airway-derived biosamples as a source of molecular information to guide patient management, with a specific emphasis on SARS-CoV-2 infection.
dc.identifier.doihttps://doi.org/10.1016/j.biopha.2024.116984
dc.identifier.issn1950-6007
dc.identifier.issn0753-3322
dc.identifier.urihttps://repositori.udl.cat/handle/10459.1/467735
dc.language.isoeng
dc.publisherElsevier
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.biopha.2024.116984
dc.relation.ispartofBiomedicine & Pharmacotherapy, 2024, vol. 177, 116984
dc.rightscc-by-nc-nd (c)The Authors, 2024
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBiomarkers
dc.subjectCOVID-19
dc.subjectMicroRNA
dc.subjectRespiratory disease
dc.subjectViral microRNA
dc.subjectVirus
dc.titleDecoding viral and host microRNA signatures in airway-derived biosamples: Insights for biomarker discovery in viral respiratory infections
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
BiomedPharmacother_a2021v177.pdf
Size:
2.57 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
639 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Articles publicats (IRBLleida)