Coping with oxidative stress. The yeast model

Simple item page
dc.contributor.authorTorre Ruiz, M. A. de la
dc.contributor.authorPujol Carrión, Núria
dc.contributor.authorSundaram, Venkatraghavan
dc.date.accessioned2015-12-12T09:12:08Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2015-01-22
dc.date.updated2015-12-12T09:12:11Z
dc.description.abstractSaccharomyces cerevisiae is an optimal model to study stress responses for various reasons: i) budding yeast genome presents a high degree of homology with the human genome; ii) there are many proteins that show an elevated functional homology with specific human proteins; iii) it is a system whose genetic manipulation is reasonably easy and cheaper than other models; iv) the possibility of working with an haploid state facilitates the study of multiple processes; v) databases are the most complete of all the eukaryotic models. Due to the latest information derived from proteomic and genomic analyses, the genetic, biochemical and molecular information available relative to this biological system is extraordinarily big and complete. In this review, we present an overview of the mechanisms unravelling sensing and transducing oxidative stress. TOR, RAS/PKA, CWI, SNF1, and HOG are the main pathways involved both in the oxidative response and in the correct entry in stationary phase. In general, TOR and RAS/PKA dowregulation and SNF1 and CWI upregulation favour both a correct defence against oxidative damage and the entry in the quiescent state. All of these pathways have counterparts in humans. The actin cytoskeleton plays a dual function as sensor and target of oxidation, in tight connection with the former signalling cascades. In budding yeast, progression through stationary phase and quiescence constitute an accepted current model to study some of the mechanisms that determine life span. Aging is a process associated to oxidative stress and it is in tight relationship with bulk autophagy and mitophagy, both are mechanisms belonging to the oxidative defence and promoters of life extension when correctly regulated by, among other elements, the signalling cascades. - See more at: http://www.eurekaselect.com/125474/article#sthash.AVRLn2Lq.dpuf
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1389450115666141020160105
dc.identifier.idgrec023563
dc.identifier.issn1389-4501
dc.identifier.urihttp://hdl.handle.net/10459.1/49260
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.2174/1389450115666141020160105
dc.relation.ispartofCurrent Drug Targets, 2015, vol. 16, num. 1, p. 2-12
dc.rights(c) Bentham Science Publishers, 2015
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAging
dc.subjectGlutaredoxins
dc.subjectMAPK
dc.subjectoxidative stress
dc.subjectsignalling
dc.subject.classificationEnvelliment
dc.subject.classificationEstrès oxidatiu
dc.subject.otherAging
dc.subject.otherOxidative stress
dc.titleCoping with oxidative stress. The yeast model
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
023563.pdf
Size:
1.16 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Articles publicats (Ciències Mèdiques Bàsiques)
Articles publicats (Grup de Recerca en Estrès Cel·lular i Supervivència en Models Eucariotes)
Articles publicats (IRBLleida)