mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity

dc.contributor.authorMota Martorell, Natàlia
dc.contributor.authorJové Font, Mariona
dc.contributor.authorPamplona Gras, Reinald
dc.date.accessioned2022-12-03T16:31:17Z
dc.date.available2022-12-03T16:31:17Z
dc.date.issued2022
dc.description.abstractDecreased content and activity of the mechanistic target of rapamycin (mTOR) signalling pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is respon sible, at least in part, for the longevous phenotype. Conversely, increased content and activity of mTOR signalling and mTORC1 are hallmarks of ageing. Additionally, constitutive and aberrant activity of mTORC1 is also found in age-related diseases such as Alzheimer’s disease (AD) and cancer. The downstream processes regulated through this network are diverse, and depend upon nutrient availability. Hence, multiple nutritional strategies capable of regulating mTORC1 activity and, consequently, delaying the ageing process and the development of age-related diseases, are under continuous study. Among these, the restriction of calories is still the most studied and ro bust intervention capable of downregulating mTOR signalling and feasible for application in the human population.ca_ES
dc.description.sponsorshipResearch by the authors was supported by the Spanish Ministry of Science, Innovation, and Universities (Ministerio de Ciencia, Innovación y Universidades, co-financed by FEDER funds from the European Union ‘A way to build Europe’, grant RTI2018-099200-B-I00), the IRBLleida-Diputació de Lleida (PIRS2021), and the Generalitat of Catalonia: Agency for Management of University and Research Grants (2017SGR696) to R.P. IRBLleida is a CERCA Programme/Generalitat of Cataloniaca_ES
dc.identifier.doihttps://doi.org/10.3390/ijms23158747
dc.identifier.idgrec033106
dc.identifier.issn1422-0067
dc.identifier.urihttp://hdl.handle.net/10459.1/84464
dc.language.isoengca_ES
dc.publisherMDPIca_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-099200-B-I00/ES/NEUROLIPIDOMICA DEL ENVEJECIMIENTO CEREBRAL HUMANO/ca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.3390/ijms23158747ca_ES
dc.relation.ispartofInternational Journal of Molecular Sciences, 2022, vol. 23, art. 8747.ca_ES
dc.rightscc-by (c) Natàlia Mota Martorell et al., 2022ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectmTORC1ca_ES
dc.subjectLongevityca_ES
dc.subjectAgeingca_ES
dc.subjectAge-related diseasesca_ES
dc.subjectMetabolismca_ES
dc.titlemTOR Complex 1 Content and Regulation Is Adapted to Animal Longevityca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
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