Development of neurons and fibers containing calcium binding proteins in the pallial amygdala of mouse, with special emphasis on those of the basolateral amygdalar complex

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dc.contributor.authorLegaz, Isabel
dc.contributor.authorOlmos, Luis
dc.contributor.authorReal, M. Ángeles
dc.contributor.authorGuirado, Salvador
dc.contributor.authorDávila, José Carlos
dc.contributor.authorMedina Hernández, Loreta Mª
dc.date.accessioned2017-01-20T10:04:16Z
dc.date.embargoEndDate2025-01-01
dc.date.issued2005
dc.description.abstractWe studied the development of neurons and fibers containing calbindin, calretinin, and parvalbumin in the mouse pallial amygdala, with special emphasis on those of the basolateral amygdalar complex. Numerous calbindin-immunoreactive (CB+) cells were observed in the incipient basolateral amygdalar complex and cortical amygdalar area from E13.5. At E16.5, CB+ cells became more abundant in the lateral and basolateral nuclei than in the basomedial nucleus, showing a pattern very similar to that of γ-aminobutyric acid (GABA)ergic neurons. Many CB+ cells observed in the pallial amygdala appeared to originate in the anterior entopeduncular area/ganglionic eminences of the subpallium. The density of CB+ cells gradually increased in the pallial amygdala until the first postnatal week and appeared to decrease later, coinciding with the postnatal appearance of parvalbumin cells and raising the possibility of a partial phenotypic shift. Calretinin (CR) immunoreactivity could be observed in a few cells and fibers in the pallial amygdala at E14.5, and by E16.5 it became a good marker of the different nuclei of the basolateral amygdalar complex. Numerous CB+ and CR+ varicosities, part of which have an intrinsic origin, were observed in the basolateral amygdalar complex from E16.5, and some surrounded unstained perikarya and/or processes before birth, indicating an early formation of inhibitory networks. Each calcium binding protein showed a distinct spatiotemporal expression pattern of development in the mouse pallial amygdala. Any alteration in the development of neurons and fibers containing calcium binding proteins of the pallial amygdala may result in important disorders of emotional and social behavior. J. Comp. Neurol. 488:492–513, 2005. © 2005 Wiley-Liss, Inc.ca_ES
dc.description.sponsorshipGrant sponsor: Ministerio de Ciencia y Tecnologı´a–Fondo Europeo de Desarrollo Regional (FEDER); Grant number: BFI2003-06453-C02-01/02; Grant sponsor: Fondo de Investigaciones Sanitarias–FEDER; Grant number: 01/0057-02; Grant sponsor: Se´neca Foundation; Grant number; PB/50/ FS/02; Grant sponsor: Health Institute Carlos III-Red Investigacio´n en Red de Las Enfermedades Neurolo´gicas (CIEN) (Nodo 318).ca_ES
dc.identifier.doihttps://doi.org/10.1002/cne.20608
dc.identifier.idgrec011376
dc.identifier.issn0021-9967
dc.identifier.urihttp://hdl.handle.net/10459.1/59054
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMICYT/PN2000-2003/BFI2003-06453-C02-01/02
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1002/cne.20608ca_ES
dc.relation.ispartofThe Journal of Comparative Neurology, 2005, vol. 488, núm. 4, p. 492–513ca_ES
dc.rights(c) Wiley-Liss, Inc. 2005ca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_ES
dc.subjectCalbindinca_ES
dc.subjectCalretininca_ES
dc.subjectParvalbuminca_ES
dc.subjectGABAca_ES
dc.titleDevelopment of neurons and fibers containing calcium binding proteins in the pallial amygdala of mouse, with special emphasis on those of the basolateral amygdalar complexca_ES
dc.typearticleca_ES
dc.type.versionpublishedVersionca_ES
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