mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity
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Date
2022
Authors
Mota Martorell, Natàlia
Jové Font, Mariona
Pamplona Gras, Reinald
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Abstract
Decreased content and activity of the mechanistic target of rapamycin (mTOR) signalling
pathway, as well as the mTOR complex 1 (mTORC1) itself, are key traits for animal species and
human longevity. Since mTORC1 acts as a master regulator of intracellular metabolism, it is respon sible, at least in part, for the longevous phenotype. Conversely, increased content and activity of
mTOR signalling and mTORC1 are hallmarks of ageing. Additionally, constitutive and aberrant
activity of mTORC1 is also found in age-related diseases such as Alzheimer’s disease (AD) and
cancer. The downstream processes regulated through this network are diverse, and depend upon
nutrient availability. Hence, multiple nutritional strategies capable of regulating mTORC1 activity
and, consequently, delaying the ageing process and the development of age-related diseases, are
under continuous study. Among these, the restriction of calories is still the most studied and ro bust intervention capable of downregulating mTOR signalling and feasible for application in the
human population.
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International Journal of Molecular Sciences, 2022, vol. 23, art. 8747.