Hybrid systems that integrate one or more renewable sources have the potential to increase the share of renewables to satisfy the energy needs of buildings. The EU-funded project SolBio-Rev is developing a novel system based on the use of solar and biomass for heating, cooling, domestic hot water (DHW), and electricity in different building typologies with high flexibility to be adapted in different climates. The system is made of advanced components including solar collectors with thermoelectric generators, a reversible ORC/heat pump, an high efficient biomass boiler and an adsorption chiller. This study includes an assessment of the potential of this system in residential buildings considering both standards and renovated buildings. Results show that the SolBio-Rev systems can cover the demand with a share of renewable of more than 80%, for heating, 100% for DHW and more than 90% for cooling in Mediterranean climates.