Porous Poly(3,4-ethylenedioxythiophene)-Based Electrodesfor Detecting Stress Biomarkers in Artificial Urine and Sweat

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2022Author
Borras, Nuria
Sánchez-Jiménez, Margarita
Alemán, Carlos
Pérez-Madrigal, Maria M.
Suggested citation
Borras, Nuria;
Sánchez-Jiménez, Margarita;
Casanovas Salas, Jordi;
Alemán, Carlos;
Pérez-Madrigal, Maria M.;
.
(2022)
.
Porous Poly(3,4-ethylenedioxythiophene)-Based Electrodesfor Detecting Stress Biomarkers in Artificial Urine and Sweat.
Macromolecular Materials and Engineering, 2022, 2200269.
https://doi.org/10.1002/mame.202200269.
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Show full item recordAbstract
When danger is perceived, the human body responds to overcome obstacles
and survive a stressful situation; however, sustained levels of stress are
associated with health disorders and diminished life quality. Hence, stress
biomarkers are monitored to control stress quantitatively. Herein, a porous
sensor (4l-COP/p) composed of poly(3,4-ethylenedioxythiophene) (PEDOT)
and poly(3,4-ethylenedioxythiophene-co-N-methylpyrrole) (COP), which is
prepared in a four-layered fashion to detect dopamine (DA) and serotonin
(5-HT), is presented. Specifically, the detection is conducted in
phosphate-buffered saline (PBS), as well as artificial urine and sweat, by
applying cyclic voltammetry. The limit of detection values obtained are as low
as 5.7 × 10−6 and 1.4 × 10−6 m for DA and 5-HT, respectively, when assessed
individually in artificial urine. When mixed in PBS, 4l-COP/p detects both
biomarkers with a resolution of 0.18 V and a sensitivity of 40 and 30 μA mm−1
for DA and 5-HT, respectively. Additionally, by theoretical calculations, the
interaction pattern that each stress biomarker establishes with the PEDOT
outer layer is elucidated. Whereas DA interacts with the 𝝅������-system of PEDOT,
5-HT forms specific hydrogen bonds with the conducting polymer chains. The
resolution value obtained depends upon such interactions. Overall, 4l-COP/p
electrodes display potential as stress sensing devices for healthcare
technologies.
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Macromolecular Materials and Engineering, 2022, 2200269European research projects
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