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dc.contributor.authorPurroy Garcia, Francisco
dc.contributor.authorVicente-Pascual, Mikel
dc.contributor.authorArque, Gloria
dc.contributor.authorBegué Gómez, Robert
dc.contributor.authorFarré, Joan
dc.contributor.authorGallego, Yhovany
dc.contributor.authorGil Villar, M. Pilar
dc.contributor.authorMauri-Capdevila, Gerard
dc.contributor.authorMontala, Nuria
dc.contributor.authorPereira, Cristina
dc.contributor.authorTorres-Querol, Coral
dc.contributor.authorVazquez-Justes, Daniel
dc.description.abstractBackground. Transient ischemic attack (TIA) provides a unique opportunity to optimize secondary preventive treatments to avoid subsequent ischemic stroke (SIS). Although atrial fibrillation (AF) is the leading cause of cardioembolism in IS and anticoagulation prevents stroke recurrence (SR), limited data exists about the risk of new-diagnosed AF (NDAF) after TIA and the consequences of the diagnostic delay. The aim of our study was to determine this risk in a cohort of TIA patients with long-term follow-up. Methods. We carried out a prospective cohort study of 723 consecutive TIA patients from January 2006 to June 2010. Median follow-up was 6.5 (5.0–9.6) years. In a subgroup of 204 (28.2%) consecutive patients, a panel of biomarkers was assessed during the first 24 h of the onset of symptoms. Multivariate analyses were performed to find out the associated factors of NDAF. Kaplan-Meier analysis was also performed to analyzed risk of SIS. Results. NDAF was indentified in 116 (16.0%) patients: 42 (36.2%) during admission, 18 (15.5%) within first year, 29 (25%) between one and five years and 27 (23.3%) beyond 5 years. NDAF was associated with sex (female) [hazard ratio (HR) 1.61 (95% CI, 1.07- 2.41)], age [[HR 1.05 (95% CI, 1.03–1.07)], previous ischemic heart disease (IHD) [HR 1.84, (95% CI 1.15–2.97)] and cortical DWI pattern [HR 2.81 (95% CI, 1.87–4.21)]. In the Kaplan-Meier analysis, NT-proBNP ≥ 218.2 pg/ml (log-rank test P < 0.001) was associated with significant risk of NDAF during the first 5 years of follow-up. Patients with NDAF after admission and before 5 years of follow-up had the highest risk of SIS (P = 0.002). Conclusion. The risk of NDAF after TIA is clinically relevant. We identified clinical and neuroimaging factors of NDAF. In addition, NT-proBNP was related to NDAF. Our results can be used to evaluate the benefit of long-term cardiac monitoring in selected patients.ca_ES
dc.description.sponsorshipThis study was supported by the Catalan Autonomous Government’s Agència de Gestió d’Ajuts Universitaris i de Recerca (2017suport a les activitats dels grups de recerca 1628) and the Instituto de Salud Carlos III, (08/1398, 11/02033, and 14/01574) and the INVICTUS plus Research Network.ca_ES
dc.publisherFrontiers Mediaca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofFrontiers in Neurology, 2022, vol. 13ca_ES
dc.rightscc-by (c) Authors, 2022ca_ES
dc.subjectTransient ischemic attackca_ES
dc.subjectAcute ischemic strokeca_ES
dc.subjectAtrial fibrillationca_ES
dc.titleRisk of New-Diagnosed Atrial Fibrillation After Transient Ischemic Attackca_ES

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