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dc.contributor.authorCasós, Kelly
dc.contributor.authorFerrer Curriu, Gemma
dc.contributor.authorSoler Ferrer, Paula
dc.contributor.authorPérez, María-Llanos
dc.contributor.authorPermanyer, Eduard
dc.contributor.authorBlasco Lucas, Arnau
dc.contributor.authorGracia Baena, Juan Manuel
dc.contributor.authorCastro, Miguel A.
dc.contributor.authorSureda, Carlos
dc.contributor.authorBarquinero, Jordi
dc.contributor.authorGaliñanes, Manuel
dc.date.accessioned2022-10-04T09:47:18Z
dc.date.available2022-10-04T09:47:18Z
dc.date.issued2017
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10459.1/83890
dc.description.abstractBackground: The diseased human myocardium is highly susceptible to ischemia/reoxygenation (I/R)-induced injury but its response to protective interventions such as ischemic preconditioning (IPreC) is unclear. Cardiac and other pre-existing clinical conditions as well as previous or ongoing medical treatment may influence the myocardial response to I/R injury and protection. This study investigated the effect of both on myocardial susceptibility to I/R-induced injury and the protective effects of IPreC. Methods and results: Atrial myocardium from cardiac surgery patients (n = 300) was assigned to one of three groups: aerobic control, I/R alone, and IPreC. Lactate dehydrogenase leakage, as a marker of cell injury, and cell viability were measured. The basal redox status was determined in samples from 90 patients. The response to I/R varied widely. Myocardium from patients with aortic valve disease was the most susceptible to injury whereas myocardium from dyslipidemia patients was the least susceptible. Tissue from females was better protected than tissue from males. Myocardium from patients with mitral valve disease was the least responsive to IPreC. The basal redox status was altered in the myocardium from patients with mitral and aortic valve disease. Conclusions: The response of the myocardium to I/R and IPreC is highly variable and influenced by the underlying cardiac pathology, dyslipidemia, sex, and the basal redox status. These results should be taken into account in the design of future clinical studies on the prevention of I/R injury and protection.ca_ES
dc.language.isoengca_ES
dc.publisherPublic Library of Scienceca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0174588ca_ES
dc.relation.ispartofPLoS One, 2017. Vol. 12, núm. 4ca_ES
dc.rightscc-by (c) Casós et al., 2017ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHeart Diseasesca_ES
dc.subjectMyocardial Ischemiaca_ES
dc.subjectRisk Factorsca_ES
dc.subjectSex Factorsca_ES
dc.titleResponse of the human myocardium to ischemic injury and preconditioning: The role of cardiac and comorbid conditions, medical treatment, and basal redox statusca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec027247
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0174588


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cc-by (c) Casós et al., 2017
Except where otherwise noted, this item's license is described as cc-by (c) Casós et al., 2017