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dc.contributor.authorZapater, Andrea
dc.contributor.authorSolelhac, Geoffroy
dc.contributor.authorSánchez de la Torre, Alicia
dc.contributor.authorGracia-Lavedan, Esther
dc.contributor.authorBenítez, Iván
dc.contributor.authorTorres, Gerard
dc.contributor.authorBatlle Garcia, Jordi de
dc.contributor.authorHaba Rubio, José
dc.contributor.authorBerger, Mathieu
dc.contributor.authorAbad, Jorge
dc.contributor.authorDurán-Cantolla, Joaquín
dc.contributor.authorUrrutia, Amaia
dc.contributor.authorMediano, Olga
dc.contributor.authorMasdeu, María José
dc.contributor.authorOrdax-Carbajo, Estrella
dc.contributor.authorMasa, Juan Fernando
dc.contributor.authorPeña, Mónica de la
dc.contributor.authorMayós Pérez, Mercè
dc.contributor.authorColoma, Ramón
dc.contributor.authorMontserrat, Josep Maria
dc.contributor.authorChiner, Eusebi
dc.contributor.authorMinguez Roure, Olga
dc.contributor.authorPascual, Lydia
dc.contributor.authorCortijo, Anunciación
dc.contributor.authorMartínez, Dolores
dc.contributor.authorDalmases, Mireia
dc.contributor.authorLee, Chi-Hang
dc.contributor.authorMcEvoy, R. Doug
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorHeinzer, Raphael
dc.contributor.authorSánchez de la Torre, Manuel
dc.date.accessioned2022-07-29T09:24:50Z
dc.date.available2022-07-29T09:24:50Z
dc.date.issued2022
dc.identifier.issn2296-858X
dc.identifier.urihttp://hdl.handle.net/10459.1/83694
dc.description.abstractIntroduction: Obstructive sleep apnea (OSA) severity is based on the apnea-hypopnea index (AHI). The AHI is a simplistic measure that is inadequate for capturing disease severity and its consequences in cardiovascular diseases (CVDs). Deleterious effects of OSA have been suggested to influence the prognosis of specific endotypes of patients with acute coronary syndrome (ACS). We aim to identify respiratory polygraphy (RP) patterns that contribute to identifying the risk of recurrent cardiovascular events in patients with ACS. Methods: Post hoc analysis of the ISAACC study, including 723 patients admitted for a first ACS (NCT01335087) in which RP was performed. To identify specific RP patterns, a principal component analysis (PCA) was performed using six RP parameters: AHI, oxygen desaturation index, mean and minimum oxygen saturation (SaO2), average duration of events and percentage of time with SaO2 < 90%. An independent HypnoLaus population-based cohort was used to validate the RP components. Results: From the ISAACC study, PCA showed that two RP components accounted for 70% of the variance in the RP data. These components were validated in the HypnoLaus cohort, with two similar RP components that explained 71.3% of the variance in the RP data. The first component (component 1) was mainly characterized by low mean SaO2 and obstructive respiratory events with severe desaturation, and the second component (component 2) was characterized by high mean SaO2 and long-duration obstructive respiratory events without severe desaturation. In the ISAACC cohort, component 2 was associated with an increased risk of recurrent cardiovascular events in the third tertile with an adjusted hazard ratio (95% CI) of 2.44 (1.07 to 5.56; p-value = 0.03) compared to first tertile. For component 1, no significant association was found for the risk of recurrent cardiovascular events. Conclusion: A RP component, mainly characterized by intermittent hypoxemia, is associated with a high risk of recurrent cardiovascular events in patients without previous CVD who have suffered a first ACS.ca_ES
dc.description.sponsorshipInstituto de Salud Carlos III (ISCIII; PI10/02763, PI10/02745, PI18/00449, and PI19/00907), co-funded by FEDER, “Una manera de hacer europa,” IRBLleida – Fundació Pifarré, CERCA Programme/Generalitat de Catalunya, SEPAR, ResMed Ltd. (Australia), Esteve-Teijin (Spain), Oxigen Salud (Spain), Associació Lleidatana de Respiratori (ALLER), and Sociedad Española de Sueño (SES). AZ is the recipient of a predoctoral fellowship “Ajuts 2021 de Promoció de la Recerca en Salut-9a edició” from IRBLleida/Diputació de Lleida. JD acknowledges receiving financial support from ISCIII (Miguel Servet 2019: CP19/00108), co-funded by the European Social Fund (ESF), “Investing in your future.” MS-d-l-T has received financial support from a “Ramón y Cajal” grant (RYC2019-027831-I) from the “Ministerio de Ciencia e Innovación – Agencia Estatal de Investigación” co-funded by the European Social Fund (ESF)/“Investing in your future.” FB received funding from from ResMed (an Australian company that develops products related to sleep apnea), the Health Research Fund, the Spanish Ministry of Health, the Spanish Respiratory Society, the Catalonian Cardiology Society, Esteve-Teijin (Spain), Oxigen Salud (Spain), and ALLER. The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.ca_ES
dc.language.isoengca_ES
dc.publisherFrontiers Mediaca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3389/fmed.2022.870906ca_ES
dc.relation.ispartofFrontiers in Medicine, 2022, vol. 9ca_ES
dc.rightscc-by (c) Authors, 2022ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAcute coronary syndromeca_ES
dc.subjectCardiovascular diseaseca_ES
dc.subjectObstructive sleep apneaca_ES
dc.subjectPrecision medicineca_ES
dc.subjectRespiratory polygraphyca_ES
dc.titleRespiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndromeca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec032562
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.3389/fmed.2022.870906


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