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dc.contributor.authorAlmodóvar Payá, Carmen
dc.contributor.authorGuardiola Ripoll, Maria
dc.contributor.authorGiralt López, Maria
dc.contributor.authorGallego, Carme
dc.contributor.authorSalgado Pineda, Pilar
dc.contributor.authorMiret, Salvador
dc.contributor.authorSalvador, Raymond
dc.contributor.authorMuñoz, María J.
dc.contributor.authorLázaro, Luisa
dc.contributor.authorGuerrero Pedraza, Amalia
dc.contributor.authorParellada, Mara
dc.contributor.authorCarrión, María I.
dc.contributor.authorCuesta, Manuel J.
dc.contributor.authorMaristany, Teresa
dc.contributor.authorSarró, Salvador
dc.contributor.authorFañanás Saura, Lourdes
dc.contributor.authorCallado, Luis F.
dc.contributor.authorArias, Bárbara
dc.contributor.authorPomarol-Clotet, Edith
dc.contributor.authorFatjó-Vilas, Mar
dc.description.abstractIncluded in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case-control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of NRN1 on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age, sex and estimated IQ). Different haplotypes encompassing the same three Single Nucleotide Polymorphisms(SNPs, rs3763180-rs10484320-rs4960155) were associated with EO in the two samples (GCT, TCC and GTT). Besides, the GTT haplotype was associated with worse N-back task performance in EO and was linked to an inefficient dorsolateral prefrontal cortex activity in subjects with EO compared to HS. Our results show convergent evidence on the NRN1 association with EO both from genetic and neuroimaging approaches, highlighting the role of neurotrophins in the pathophysiology of SZ.ca_ES
dc.description.sponsorshipThis study received funding provided by: (i) Fundación Alicia Koplowitz; (ii) Acadèmiade les Ciències Mèdiques i de la Salut de Catalunya i de Balears (predoctoral contract to C.A.-P.);(iii) the Instituto de Salud Carlos III through a PFIS predoctoral contract to M.G.-R. (FI19/0352) and aMiguel Servet contract to M.F.-V. (CP20/00072), co-funded by European Regional Development Fund(ERDF)/European Social Fund “Investing in your future”; (iv) the Comissionat per a Universitatsi Recerca del DIUE of the Generalitat de Catalunya (Agència de Gestiód’Ajuts Universitaris i deRecerca (AGAUR), 2017SGR1271 and 2017SGR1577)ca_ES
dc.relation.isformatofReproducció del document publicat a :
dc.relation.ispartofInternational Journal of Molecular Science, 2022, vol. 23, núm. 13ca_ES
dc.rightscc-by (c) the authors, 2022ca_ES
dc.subjectAge at onsetca_ES
dc.subjectFunctional magnetic resonance imaging (fMRI)ca_ES
dc.subjectSchizophrenia-spectrum disordersca_ES
dc.subjectWorking memoryca_ES
dc.titleNRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approachesca_ES

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