Long-lived Humans Have a Unique Plasma Sphingolipidome
Pradas Barriga, Irene
Galo-Licona, José Daniel
Viña Ribes, José
Meikle, Peter J.
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A species-specific lipidome profile is an inherent feature linked to longevity in the animal kingdom. However, there is a lack of lipidomic studies on human longevity. Here, we use mass spectrometry-based lipidomics to detect and quantify 151 sphingolipid molecular species and use these to define a phenotype of healthy humans with exceptional life span. Our results demonstrate that this profile specifically comprises a higher content of complex glycosphingolipids (hexosylceramides and gangliosides), and lower levels of ceramide species from the de novo pathway, sphingomyelin and sulfatide; while for ceramide-derived signaling compounds, their content remains unchanged. Our findings suggest that structural glycosphingolipids may be more relevant to achieve the centenarian condition than signaling sphingolipids.
Is part ofThe Journals of Gerontology Series A, 2022, , vol. 77, núm. 4, p. 728–735
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