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dc.contributor.authorBauer, Kylynda C.
dc.contributor.authorLittlejohn, Paula T.
dc.contributor.authorAyala Jové, Ma. Victoria (Maria Victoria)
dc.contributor.authorCreus Cuadros, Anna
dc.contributor.authorFinlay, Barton Brett
dc.date.accessioned2022-05-18T07:25:51Z
dc.date.available2022-05-18T07:25:51Z
dc.date.issued2022
dc.identifier.issn0016-5085
dc.identifier.urihttp://hdl.handle.net/10459.1/83313
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is a chronic con dition affecting one quarter of the global population. Although primarily linked to obesity and metabolic syn drome, undernutrition and the altered (dysbiotic) gut microbiome influence NAFLD progression. Both undernu trition and NAFLD prevalence are predicted to considerably increase, but how the undernourished gut microbiome contributes to hepatic pathophysiology remains far less studied. Here, we present undernutrition conditions with fatty liver features, including kwashiorkor and micro nutrient deficiency. We then review the gut microbiota-liver axis, highlighting key pathways linked to NAFLD progres sion within both overnutrition and undernutrition. To conclude, we identify challenges and collaborative possi bilities of emerging multiomic research addressing the pa thology and treatment of undernourished NAFLD.ca_ES
dc.description.sponsorshipAuthors from the Finlay lab are grateful for funding through a Foundation Grant from the Canadian Institutes of Health Research. The Ayala Lab has received financial support from Spanish Ministries and the Generalitat of Catalonia.ca_ES
dc.language.isoengca_ES
dc.publisherAGA Instituteca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1053/j.gastro.2022.01.058ca_ES
dc.relation.ispartofGastroenterology, 2022, vol. 162, núm. 7, p. 1858–1875ca_ES
dc.rightscc-by-nc-nd (c) Authors, 2022ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGut Microbiomeca_ES
dc.subjectNAFLDca_ES
dc.subjectGut-Liver Axisca_ES
dc.subjectMalnutritionca_ES
dc.subjectUndernutritionca_ES
dc.titleNonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspectiveca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1053/j.gastro.2022.01.058


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Except where otherwise noted, this item's license is described as cc-by-nc-nd (c) Authors, 2022