Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort

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2021Author
Zuil, María
Cabo Gambín, Ramón
Manzano Senra, Carlos
Moncusí Moix, Anna
Gort Paniello, Clara
de Gonzalo Calvo, David
Molinero, Marta
Vengoechea Aragoncillo, José Javier
Comella, Thais
Batlle Garcia, Jordi de
Torres, Gerard
Torres, Antoni
González, Jessica
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Zuil, María;
Benítez, Iván;
Cabo Gambín, Ramón;
Manzano Senra, Carlos;
Moncusí Moix, Anna;
Gort Paniello, Clara;
...
González, Jessica.
(2021)
.
Clinical management and outcome differences between first and second waves among COVID-19 hospitalized patients: A regional prospective observational cohort.
PLoS One, 2021, vol. 16, núm. 10.
https://doi.org/10.1371/journal.pone.0258918.
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The objective was to describe the clinical characteristics and outcomes of hospitalized COVID-19 patients during the two different epidemic periods. Prospective, observational, cohort study of hospitalized COVID-19. A total of 421 consecutive patients were included, 188 during the first period (March-May 2020) and 233 in the second wave (July-December 2020). Clinical, epidemiological, prognostic and therapeutic data were compared. Patients of the first outbreak were older and more comorbid, presented worse PaO2/FiO2 ratio and an increased creatinine and D-dimer levels at hospital admission. The hospital stay was shorter (14.5[8;29] vs 8[6;14] days, p<0.001), ICU admissions (31.9% vs 13.3%, p<0.001) and the number of patients who required mechanical ventilation (OR = 0.12 [0.05–10.26]; p<0.001) were reduced. There were no significant differences in hospital and 30-day after discharge mortality (adjusted HR = 1.56; p = 0.1056) or hospital readmissions. New treatments and clinical strategies appear to improve hospital length, ICU admissions and the requirement for mechanical ventilation. However, we did not observe differences in mortality or readmissions.
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PLoS One, 2021, vol. 16, núm. 10European research projects
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