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dc.contributor.authorTarga, Adriano
dc.contributor.authorBenítez, Iván
dc.contributor.authorDakterzada, Farida
dc.contributor.authorFontenele Araujo, John
dc.contributor.authorMinguez Roure, Olga
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorBlennow, Kaj
dc.contributor.authorBarbé Illa, Ferran
dc.contributor.authorPiñol Ripoll, Gerard
dc.description.abstractBackground:Alterations in circadian rhythms are present in the presymptomatic stage of Alzheimer’s disease (AD),possibly contributing to its pathogenesis. However, it is unknown whether such alterations are associated withworse outcomes once individuals are diagnosed with symptomatic disease. We aimed to evaluate the associationbetween the circadian rest-activity pattern and AD-related features in patients with mild-moderate AD.Methods:We assessed the circadian rest-activity pattern of consecutive patients with mild-moderate AD throughactigraphy for 14 days. Cerebrospinal fluid was obtained to determine the levels of important pathological markersincluding amyloid-beta protein (Aβ42), phosphorylated tau (P-tau), total tau (T-tau), and neurofilament light (NF-L).Neuropsychological evaluation was conducted at the beginning of the study and after 12 months of follow-up.Linear regression models were performed considering the global population and Aβ42+ patients only.Results:The cohort included 100 patients with mild-moderate AD. The median age [p25;p75] was 76.0 [73.0;80.0]years and 63.0% were female. Older age (effect size [SE] of 0.324 [0.096];p= 0.001) and male sex (0.780 [0.193];p=0.001) were associated with increased fragmentation and decreased synchronization of the rhythm, respectively.After adjusting for age, sex, and season of the year, increased levels of T-tau (effect size [95% CI] of 0.343 [0.139 to0.547];p= 0.001) and NF-L (0.444 [0.212 to 0.676];p= 0.001) were associated with a higher amplitude of the rest-activity rhythm. Increased fragmentation of the rhythm at baseline was associated with greater cognitive declineafter one year of follow-up independent of age, sex, T-tau/Aβ42 ratio, educational level, and season of the year (−0.715 [−1.272 to−0.157];p= 0.013). Similar findings were obtained considering only the Aβ42+ patients.Conclusions:Our results suggest a potential role of the circadian rest-activity pattern in predicting the cognitivedecline of patients with mild-moderate AD. Further studies are warranted to confirm these findings and toelucidate whether there is causality among the observed associations.ca_ES
dc.description.sponsorshipGeneralitat of Catalonia, Department of Health (PERIS 2019 SLT008/18/00050)and“Fundació La Marató TV3”(464/C/2014) to GPR. Co-financed by FEDERfunds from the European Union (‘A way to build Europe’). IRBLleida is aCERCA Programme/Generalitat of Catalonia. FD was supported by Agencyfor Management of University and Research Grants (FI_B100153)ca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofAlzheimer's Research & Therapy, 2021, vol. 13ca_ES
dc.rightscc-by (c) Authors, 2021ca_ES
dc.subjectAlzheimer’s diseaseca_ES
dc.subjectCircadian rest-activity patternca_ES
dc.subjectIntradaily variabilityca_ES
dc.subjectNeurofilament lightca_ES
dc.subjectCognitive declineca_ES
dc.titleThe circadian rest-activity pattern predicts cognitive decline among mild-moderate Alzheimer's disease patientsca_ES

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