Gut epithelial barrier markers in patients with obstructive sleep apnea

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2016Author
Barceló Bennasar, Antònia
Esquinas López, Cristina
Robles, Juan
Piérola, Javier
Peña, Mónica de la
Aguilar, Irene
Morell Garcia, Daniel
Alonso, Alberto
Toledo Pons, Nuria
Suggested citation
Barceló Bennasar, Antònia;
Esquinas López, Cristina;
Robles, Juan;
Piérola, Javier;
Peña, Mónica de la;
Aguilar, Irene;
...
Barbé Illa, Ferran.
(2016)
.
Gut epithelial barrier markers in patients with obstructive sleep apnea.
Sleep Medicine, 2016, vol. 26, p. 12-15.
https://doi.org/10.1016/j.sleep.2016.01.019.
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Background: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters.
Results: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0.04). Zonulin levels were similar between groups. Significant relationships were observed between zonulin levels and waist circumference (p < 0.05), glucose (p < 0.05), and insulin (p < 0.05). In addition, in the OSA group, zonulin levels correlated negatively with the mean nocturnal oxygenation saturation (p < 0.05) and positively with total cholesterol (p < 0.05), alanine aminotransferase (ALT) (p < 0.005), aminotransferase (AST) (p < 0.01), gamma glutamyltransferase (GGT) (p < 0.005), and high-sensitivity C-reactive protein (hs-CRP) (p < 0.05). Multivariate analysis showed that associations between zonulin and ALT, AST, and hs-CRP were attenuated, but not eliminated, after adjustment for other variables.
Conclusions: The results of this study suggest that OSA is a risk factor for intestinal damage, regardless of metabolic profile, and that intestinal permeability might be a possible contributor to nonalcoholic fatty liver disease in patients with OSA.
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Sleep Medicine, 2016, vol. 26, p. 12-15European research projects
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