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dc.contributor.authorMorales, Lorena
dc.contributor.authorGonzález Alonso, Alba
dc.contributor.authorDesfilis, Ester
dc.contributor.authorMedina Hernández, Loreta Mª
dc.description.abstractTaking advantage of two Otp-specific reporter lines of transgenic mice (Otp-eGFP and Otp-Cre; Rpl22-HA), we identify and describe different Otp cell populations across various pallial regions, including the pallial amygdala, the piriform cortex, the mesocortex, the neocortex, and the hippocampal complex. Some of these populations can be followed throughout development, suggesting migration from external sources (for example, those of the pallial amygdala and at least some of the cingulate cortex). Other cells become visible during postnatal development (some of those in the neocortex and hippocampal formation) or in adulthood (those of the parahippocampal lobe), and seem to be produced locally. We discuss the possible role of Otp in these different populations during different moments of ontogenesis. We also analyze the connectivity patterns of some of these cells and discuss their functional implications. For example, our data suggest that Otp cells of the pallial amygdala might be engaged in networks with other Otp cells of the medial amygdala with the same embryonic origin, and may regulate specific aspects of social behavior. Regarding Otp cells in the parahippocampal lobe, they seem to be projection neurons and may regulate hippocampal function during spatial navigation and memory formation. The two reporter transgenic mice employed here provide very powerful tools for high precision studies on these different Otp cells of the pallium, but careful attention should be paid to the age and to differences between lines.ca_ES
dc.description.sponsorshipFunded by grants from the Spanish Ministerio de Economía y Competitividad and Fondo Europeo de Desarrollo Regional (FEDER) (Grant no. BFU2015-68537-R) and Spanish Ministerio de Ciencia e Innovación (Agencia Estatal de Investigación, Grant No. PID2019-108725RB-100). LMo had a predoctoral fellowship from Universitat de Lleida i Ajuts Jade Plus, and a predoctoral contract from IRBLleida/Diputació de Lleida. AG-A had a predoctoral fellowship from Universitat de Lleida i Ajuts Jade Plus, and currently holds a predoctoral contract from AGAUR (Generalitat de Catalunya 2021 FI_B00353).ca_ES
dc.publisherFrontiers Mediaca_ES
dc.relationMINECO/PN 2013-2016/BFU2015-68537-Rca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofFrontiers in Neural Circuits, 2022, vol. 16ca_ES
dc.rightscc-by (c) Morales, González-Alonso, Desfilis and Medina, 2022ca_ES
dc.subjectBasomedial amygdalaca_ES
dc.subjectCingulate bundleca_ES
dc.subjectCingulate cortexca_ES
dc.subjectCortical amygdalaca_ES
dc.subjectFrontal cortexca_ES
dc.subjectParahippocampal lobeca_ES
dc.titlePrecise Mapping of Otp Expressing Cells Across Different Pallial Regions Throughout Ontogenesis Using Otp-Specific Reporter Transgenic Miceca_ES

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cc-by (c) Morales, González-Alonso, Desfilis and Medina, 2022
Except where otherwise noted, this item's license is described as cc-by (c) Morales, González-Alonso, Desfilis and Medina, 2022