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dc.contributor.authorSánchez Peña, Enric
dc.contributor.authorKerkeni, M.
dc.contributor.authorHernández García, Marta
dc.contributor.authorGavaldá, Ricard
dc.contributor.authorRius, Ferran
dc.contributor.authorSauret, Ariadna
dc.contributor.authorTorres, Gerard
dc.contributor.authorBermúdez López, Marcelino
dc.contributor.authorFernández i Giráldez, Elvira
dc.contributor.authorCastro-Boqué, Eva
dc.contributor.authorPurroy Garcia, Francisco
dc.contributor.authorMauricio Puente, Dídac
dc.contributor.authorFarràs-Sallés, Cristina
dc.contributor.authorButi, Miquel
dc.contributor.authorGodoy i García, Pere
dc.contributor.authorPamplona Gras, Reinald
dc.contributor.authorLecube Torelló, Albert
dc.description.abstractA large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.3 [25.4;31.6] kg/m2, and a prevalence of prediabetes of 34.5%. Participants with prediabetes showed higher SAF than control participants (2.0 [1.7;2.2] vs. 1.9 [1.7;2.2], p < 0.001). However, HbA1c was not significantly correlated with SAF levels (r = 0.026, p = 0.090). In addition, the SAF level was not independently associated with prediabetes (OR = 1.12 (0.96 to 1.30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0.52 (0.50 to 0.54), sensitivity = 0.61, and 1-specificity = 0.56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population.ca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofNutrients, 2022, vol. 14, núm. 5ca_ES
dc.rightscc-by (c) Authors, 2022ca_ES
dc.subjectAdvanced glycation end-productsca_ES
dc.subjectGlycosylated hemoglobinca_ES
dc.subjectSkin autofluorescenceca_ES
dc.titleWeak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Studyca_ES

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