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dc.contributor.authorGranado-Serrano, Ana Belén
dc.contributor.authorMartín Garí, Meritxell
dc.contributor.authorSánchez, Virginia
dc.contributor.authorRiart Solans, Marissa
dc.contributor.authorLafarga Giribets, Antonia
dc.contributor.authorBerdún Hernández, Rebeca
dc.contributor.authorVilaprinyo Terré, Ester
dc.contributor.authorPortero Otín, Manuel
dc.contributor.authorSerrano Casasola, José Carlos Enrique
dc.date.accessioned2022-05-02T08:42:53Z
dc.date.available2022-05-02T08:42:53Z
dc.date.issued2022
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10459.1/83196
dc.description.abstractThis study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that included three different fibre types (mainly insoluble, soluble, and antioxidant fibre) supplemented (19.2 g/day) during 2 months in individuals with hypercholesterolemia was developed. Changes in faecal microbiota and blood lipid profile after fibre supplementation were determined. In all volunteers, regardless of fibre type, an increase in the abundance of Bifidobacterium was observed, and similarly, an inverse relationship between faecal propionic acid and blood LDL-cholesterol, LDL particle size, and LDL/HDL particle ratio (p-values 0.0067, 0.0002, and 0.0067, respectively) was observed. However, not all volunteers presented an improvement in lipid profile. The non-responders to fibre treatment showed a decrease in microbiota diversity (Shannon and Simpson diversity index p-values of 0.0110 and 0.0255, respectively) after the intervention; where the reduction in short-chain fatty acids (SCFAs) producing bacterial genera such as Clostridium XIVa and Ruminococcus after dietary fibre treatment was the main difference. It was concluded that the non-responsiveness to dietary fibre treatment might be mediated by the lack of ability to maintain a stable SCFA producing bacteria diversity and composition after extra fibre intake.ca_ES
dc.description.sponsorshipThe research leading to these results has received funding from the People Programme (Marie Curie Actions) of the Seventh Framework Programme of the European Union (FP7/2007-2013) under REA grant agreement no. 600388 (TECNIOspring Progamme) and from the Agency for Business Competitiveness of the Government of Catalonia ACCIÓ that support the fellowship given to Ana Belén Granado-Serrano (TECSPR14-0-0023)ca_ES
dc.language.isoengca_ES
dc.publisherMDPIca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/nu14030525ca_ES
dc.relation.ispartofNutrient, 2022, vol. 14, núm. 3ca_ES
dc.rightscc-by (c) Authors, 2022ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDietary fibreca_ES
dc.subjectCholesterolca_ES
dc.subjectBlood lipid profileca_ES
dc.subjectColonic microbiotaca_ES
dc.titleColonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemiaca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec032461
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.3390/nu14030525
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/600388ca_ES


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