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dc.contributor.authorCalderón-Pérez, Lorena
dc.contributor.authorSuárez-García, Susana
dc.contributor.authorPedret, Anna
dc.contributor.authorSuárez, Manuel
dc.contributor.authorLlauradó, Elisabet
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorBas, Josep M. del
dc.contributor.authorCaimari, Antoni
dc.contributor.authorPuiggrós, Francesc
dc.contributor.authorArola, Lluís
dc.contributor.authorSolà, Rosa
dc.contributor.authorValls, Rosa M.
dc.description.abstractBackground & aims: Whether bioactive lysophospholipids (lyso-PLs) and trimethylamine-N-oxide (TMAO) serve as non-invasive biomarkers in early human hypercholesterolemia (HC) is unknown. This study aimed to assess whether serum lyso-PLs and plasma TMAO may be suitable susceptibility/risk biomarkers of HC in humans. Secondarily, we aimed to evaluate the relationships between targeted metabolites, diet composition and circulating liver transaminases, and verify these results in hamsters. Methods: A targeted metabolomics and lipidomics approach determined plasma TMAO and serum lysophosphatidylcholines (lyso-PCs) and lysophosphatidylethanolamines (lyso-PEs) in low (L-LDL-c) and moderate to high (MH-LDL-c) LDL-cholesterol subjects. Additionally, the relationships between targeted metabolites, liver transaminases and diet, particularly fatty acid intake, were tested. In parallel, plasma and liver lyso-PL profiles were studied in 16 hamsters fed a moderate high-fat (HFD) or low-fat (LFD) diet for 30 days. Results: Predictive models identified lyso-PC15:0 and lyso-PE18:2 as the most discriminant lyso-PLs among groups. In MH-LDL-c (n ¼ 48), LDL-cholesterol and saturated FAs were positively associated with lyso-PC15:0, whereas in L-LDL-c (n ¼ 70), LDL-cholesterol and polyunsaturated fatty acids (PUFAs) were negatively and positively related to lyso-PE18:2, respectively. Interestingly, in MH-LDL-c, the lower lyso-PE 18:2 concentrations were indicative of higher LDL-cholesterol levels. Intrahepatic accumulation of lyso-PLs-containing essential n-6 PUFAs, including lyso-PE18:2, were higher in HFD-fed hamsters than LFD-fed hamsters.ca_ES
dc.description.sponsorshipThe research leading to these results was supported by the Eu-ropean Commission through its Seventh Framework Programme "BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food" Project (FP7-KBBE-20 09-3 BIOCLAIMS) under grant agreement number 244995. Additionally, it was financially supported by the Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation under grant agreement: TEC-NOMIFOOD project (CER-20191010)
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofClinical nutrition, 2022, vol. 41, núm. 2, p.489-499ca_ES
dc.rightscc-by, (c) Calderón et al., 2022ca_ES
dc.subjectPolyunsaturated fatty acidsca_ES
dc.titleSerum lysophospholipidome of dietary origin as a suitable susceptibility/risk biomarker of human hypercholesterolemia: a cross-sectional studyca_ES

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