Show simple item record

Serum lysophospholipidome of dietary origin as a suitable susceptibility/risk biomarker of human hypercholesterolemia: a cross-sectional study

dc.contributor.authorCalderón-Pérez, Lorena
dc.contributor.authorSuárez-García, Susana
dc.contributor.authorPedret, Anna
dc.contributor.authorSuárez, Manuel
dc.contributor.authorLlauradó, Elisabet
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorBas, Josep M. del
dc.contributor.authorCaimari, Antoni
dc.contributor.authorPuiggrós, Francesc
dc.contributor.authorArola, Lluís
dc.contributor.authorSolà, Rosa
dc.contributor.authorValls, Rosa M.
dc.date.accessioned2022-04-27T10:19:50Z
dc.date.available2022-04-27T10:19:50Z
dc.date.issued2022
dc.identifier.issn1532-1983
dc.identifier.urihttp://hdl.handle.net/10459.1/83162
dc.description.abstractBackground & aims: Whether bioactive lysophospholipids (lyso-PLs) and trimethylamine-N-oxide (TMAO) serve as non-invasive biomarkers in early human hypercholesterolemia (HC) is unknown. This study aimed to assess whether serum lyso-PLs and plasma TMAO may be suitable susceptibility/risk biomarkers of HC in humans. Secondarily, we aimed to evaluate the relationships between targeted metabolites, diet composition and circulating liver transaminases, and verify these results in hamsters. Methods: A targeted metabolomics and lipidomics approach determined plasma TMAO and serum lysophosphatidylcholines (lyso-PCs) and lysophosphatidylethanolamines (lyso-PEs) in low (L-LDL-c) and moderate to high (MH-LDL-c) LDL-cholesterol subjects. Additionally, the relationships between targeted metabolites, liver transaminases and diet, particularly fatty acid intake, were tested. In parallel, plasma and liver lyso-PL profiles were studied in 16 hamsters fed a moderate high-fat (HFD) or low-fat (LFD) diet for 30 days. Results: Predictive models identified lyso-PC15:0 and lyso-PE18:2 as the most discriminant lyso-PLs among groups. In MH-LDL-c (n ¼ 48), LDL-cholesterol and saturated FAs were positively associated with lyso-PC15:0, whereas in L-LDL-c (n ¼ 70), LDL-cholesterol and polyunsaturated fatty acids (PUFAs) were negatively and positively related to lyso-PE18:2, respectively. Interestingly, in MH-LDL-c, the lower lyso-PE 18:2 concentrations were indicative of higher LDL-cholesterol levels. Intrahepatic accumulation of lyso-PLs-containing essential n-6 PUFAs, including lyso-PE18:2, were higher in HFD-fed hamsters than LFD-fed hamsters.ca_ES
dc.description.sponsorshipThe research leading to these results was supported by the Eu-ropean Commission through its Seventh Framework Programme "BIOmarkers of Robustness of Metabolic Homeostasis for Nutrigenomics-derived Health CLAIMS Made on Food" Project (FP7-KBBE-20 09-3 BIOCLAIMS) under grant agreement number 244995. Additionally, it was financially supported by the Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation under grant agreement: TEC-NOMIFOOD project (CER-20191010)
dc.language.isoengca_ES
dc.publisherElsevierca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1016/j.clnu.2021.11.033ca_ES
dc.relation.ispartofClinical nutrition, 2022, vol. 41, núm. 2, p.489-499ca_ES
dc.rightscc-by, (c) Calderón et al., 2022ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectLysophospholipidsca_ES
dc.subjectLysophosphatidylcholinesca_ES
dc.subjectLysophosphatidylethanolaminesca_ES
dc.subjectTrimethylamine-N-Oxideca_ES
dc.subjectHypercholesterolemiaca_ES
dc.subjectPolyunsaturated fatty acidsca_ES
dc.titleSerum lysophospholipidome of dietary origin as a suitable susceptibility/risk biomarker of human hypercholesterolemia: a cross-sectional studyca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1016/j.clnu.2021.11.033


Files in this item

Thumbnail
Name:
license_rdf
Size:
908bytes
Format:
application/rdf+xml
View/Open
Thumbnail
Name:
clinut_a2022v41n2p489.pdf
Size:
1.500Mb
Format:
PDF
View/Open

This item appears in the following Collection(s)

Show simple item record

cc-by, (c) Calderón et al., 2022
Except where otherwise noted, this item's license is described as cc-by, (c) Calderón et al., 2022