Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study

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Data de publicació
2022Autor/a
López Cano, Carolina
Ciudin, Andreea
Tinahones, Francisco José
Dalmases, Mireia
García Ramírez, Marta
Soto, Alfonso
Michela Gaeta, Anna
Pellitero, Silvia
Martí, Raquel
Hernández, Cristina
Simó, Rafael
Citació recomanada
López Cano, Carolina;
Ciudin, Andreea;
Sánchez Peña, Enric;
Tinahones, Francisco José;
Barbé Illa, Ferran;
Dalmases, Mireia;
...
Lecube Torelló, Albert.
(2022)
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Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study.
Diabetes 2022, vol. 71, núm. 2, p. 315–320.
https://doi.org/10.2337/db21-0688.
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To evaluate the effect of liraglutide, a glucagon-like peptide 1 receptor agonist, on pulmonary function and serum levels of surfactant protein D (SP-D) in type 2 diabetes. A double-blind, randomized, crossover, placebo-controlled clinical trial comprising 76 patients with a baseline forced expiratory volume in 1 s <90% of that predicted. Liraglutide was administered for 7 weeks (2 weeks of titration plus 5 weeks at 1.8 mg daily). This short duration was intentional to minimize weight loss as a potential confounding factor. Serum level of SP-D was used as a biomarker of alveolar-capillary barrier integrity. Liraglutide exerted a positive impact on forced vital capacity (FVC) in comparison with placebo (ΔFVC 5.2% of predicted [from 0.8 to 9.6]; P = 0.009). No differences in the other pulmonary variables were observed. Participants under liraglutide treatment also experienced a decrease in serum SP-D (P = 0.038). The absolute change in FVC correlated with final serum SP-D in participants receiving liraglutide (r = −0.313, P = 0.036). Stepwise multivariate regression analysis showed that final serum SP-D independently predicted changes in FVC. In conclusion, liraglutide increased FVC in patients with type 2 diabetes. This effect was associated with a significant decrease of circulating SP-D, thus pointing to a beneficial effect in the alveolar-capillary function.