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dc.contributor.authorMoreno, Sara
dc.contributor.authorMaiques Carlos, Oscar
dc.contributor.authorBarceló Gómez, Carla
dc.contributor.authorRomero, Marta
dc.contributor.authorSantacana Espasa, Maria
dc.contributor.authorGómez, Ignacio
dc.contributor.authorCuevas Sánchez, Dolors
dc.contributor.authorVelasco Sánchez, Ana
dc.contributor.authorVeà Jódar, Àlvar
dc.contributor.authorMacià Armengol, Anna
dc.contributor.authorBoix, Ramon
dc.contributor.authorValls Marsal, Joan
dc.contributor.authorGatius Calderó, Sònia
dc.contributor.authorCantí Nicolás, Carles
dc.contributor.authorMatias-Guiu, Xavier
dc.contributor.authorSoria, Xavier
dc.contributor.authorMartí Laborda, Rosa Ma.
dc.description.abstractBRAF/V600E mutation and other cell growth/growth-control mechanisms are involved in naevogenesis and melanomagenesis. Immunoexpression of BRAF/V600E and other molecules (p16, phosphatase and tensin homologue (PTEN), Ki67, hTERT and Cav3.1 and 3.2 calcium channels) were investigated in 80 histopatho­logically and dermoscopically classified acquired naevi. Regarding BRAF/V600E, dysplastic naevi showed lower immunostaining than common naevi, which was significant in comparison with intradermal naevi, which showed the highest BRAF/V600E histoscore. Junctional naevi showed the lowest BRAF/V600E levels. Globular/cobblestone and reticular dermoscopic patterns were consistently associated with high and low BRAF/V600E immunoexpression, respectively, but Zalaudek’s peripheral globule pattern (CR/PG) showed the highest BRAF/V600E immunoexpression. Among global patterns, the previously not investigated multicomponent pattern showed the lowest BRAF/V600E immunoexpression. Regarding the remaining biomarkers, new immunohistochemical features were found, in particular p16 and PTEN low expression in multicomponent pattern; and Ki67, hTERT and Cav.3.1 high expression in CR/PG. In conclusion, histopathology and dermoscopy provide complementary information regarding the biology of melanocytic naevi.ca_ES
dc.description.sponsorshipThis research was supported by grants from Instituto de Salud Carlos III/Fondo Europeo de Desarrollo Regional. “Una manera de hacer Europa” (FIS-PI12/00260 and PI15/00711 to RMM and PI18/00573 to RMM and AM) and Generalitat de Catalunya (2017/SGR1368 to XMG). RMM, MS, AV, JV, SG and XMG were supported by Centro de Investigación Biomédica en Red Cáncer (CB16/12/0023). SM and OM held pre-doctoral fellowships from IRBLleida/Diputació de Lleida and CB a pre-doctoral fellowship from the University of Lleida. AM holds a postdoctoral fellowship from Asociación Española contra el Cáncer. Tumour samples were processed by IRBLleida (B.0000682) Biobank integrated in the Spanish National Biobank Network (PT17/0015/0027) and Xarxa de Bancs de Tumors de Catalunya following standard operating procedures with the appropriate approval of the Ethics and Scientific Committeeca_ES
dc.publisherSociety for Publication of Acta Dermato-Venereologicaca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofActa Dermato-Venereologica, 2021, vol. 101, núm. 11, p. 1-7ca_ES
dc.rightscc-by-nc (c) Authors, 2021ca_ES
dc.subjectAcquired melanocytic naevusca_ES
dc.subjectSenescence markersca_ES
dc.subjectT-type calcium channelsca_ES
dc.titleDifferential Immunoexpression of BRAF/V600E, Senescence Markers, PTEN, and T-type Calcium Channels in Acquired Naevi According to their Histopathological and Dermoscopic Classificationca_ES

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