Resveratrol-enriched grape seed oil (Vitis vinifera L.) protects from white fat dysfunction in obese mice

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2019Author
Mahanna, Mohammed
Millan-Linares, Maria C.
Grao-Cruces, Elena
Claro, Carmen
Toscano, Rocío
Rodriguez-Martin, Noelia M.
Naranjo, Maria C.
Montserrat de la Paz, Sergio
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Mahanna, Mohammed;
Millan-Linares, Maria C.;
Grao-Cruces, Elena;
Claro, Carmen;
Toscano, Rocío;
Rodriguez-Martin, Noelia M.;
...
Montserrat de la Paz, Sergio.
(2019)
.
Resveratrol-enriched grape seed oil (Vitis vinifera L.) protects from white fat dysfunction in obese mice.
Journal of Functional Foods, 2019, vol. 62, núm. 103546, p.1-10.
https://doi.org/10.1016/j.jff.2019.103546.
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Grape skin and seed oil are winemaking by-products with a potential nutraceutical value. This study aimed to evaluate the effects of resveratrol-enriched grape seed oil (GSO) administration on white adipose tissue (WAT) dysfunction in obese mice. Male mice were divided into four groups (n = 10/group): the chow diet (CD) group; the high-fat diet (HFD) group was fed fat from milk cream (rich in saturated fatty acids), and the HFD-GSO and HFD-GSO+R groups were fed fat from GSO in absence or presence of resveratrol (200 mg/kg/day), respectively. Glucose tolerance, metabolic profile, and inflammatory cytokines were determined. Histological studies were carried out in WAT and brown AT, RT-qPCR and western blot were used to determine the gene and protein expression. In the setting of obesity, our results unveil a novel nutritional value for winemaking by-products by which resveratrol-enriched GSO from Vitis vinifera L. in obesogenic diets favor WAT and immunometabolic homeostasis.