Plasma methionine metabolic profile is associated with longevity in mammals

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Issue date
2021-06-11Suggested citation
Mota Martorell, Natàlia;
Jové Font, Mariona;
Berdún Hernández, Rebeca;
Pamplona Gras, Reinald;
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(2021)
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Plasma methionine metabolic profile is associated with longevity in mammals.
Communications Biology, 2021, vol. 4, article number: 725.
https://doi.org/10.1038/s42003-021-02254-3.
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Methionine metabolism arises as a key target to elucidate the molecular adaptations underlying animal longevity due to the negative association between longevity and methionine content. The present study follows a comparative approach to analyse plasma methionine metabolic profile using a LC-MS/MS platform from 11 mammalian species with a longevity ranging from 3.5 to 120 years. Our findings demonstrate the existence of a species-specific plasma profile for methionine metabolism associated with longevity characterised by: i) reduced methionine, cystathionine and choline; ii) increased non-polar amino acids; iii) reduced succinate and malate; and iv) increased carnitine. Our results support the existence of plasma longevity features that might respond to an optimised energetic metabolism and intracellular structures found in long-lived species.