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The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

dc.contributor.authorTorres, Antoni
dc.contributor.authorMotos, Anna
dc.contributor.authorRiera, Jordi
dc.contributor.authorFernández Barat, Laia
dc.contributor.authorCeccato, Adrián
dc.contributor.authorPérez Arnal, Raquel
dc.contributor.authorGarcía Gasulla, Dario
dc.contributor.authorPeñuelas, Oscar
dc.contributor.authorLorente, José Ángel
dc.contributor.authorRodríguez, Alejandro
dc.contributor.authorde Gonzalo Calvo, David
dc.contributor.authorAlmansa, Raquel
dc.contributor.authorGabarrús, Albert
dc.contributor.authorMenéndez, Rosario
dc.contributor.authorBermejo Martin, Jesús F.
dc.contributor.authorFerrer, Ricard
dc.contributor.authorAmaya Villar, Rosario
dc.contributor.authorAñón, José M.
dc.contributor.authorBarberà, Carme
dc.contributor.authorBarberán, José
dc.contributor.authorBlandino Ortiz, Aaron
dc.contributor.authorBustamante Munguira, Elena
dc.contributor.authorCaballero, Jesús
dc.contributor.authorCarbajales, Cristina
dc.contributor.authorCarbonell, Nieves
dc.contributor.authorCatalán González, Mercedes
dc.contributor.authorGalbán, Cristóbal
dc.contributor.authorGumucio Sanguino, Víctor D.
dc.contributor.authorde la Torre, Maria del Carmen
dc.contributor.authorDíaz, Emili
dc.contributor.authorEstella, Ángel
dc.contributor.authorGallego, Elena
dc.contributor.authorGarcía Garmendia, José Luis
dc.contributor.authorGarnacho Montero, José
dc.contributor.authorGómez, José Manuel
dc.contributor.authorHuerta, Arturo
dc.contributor.authorJorge García, Ruth Noemí
dc.contributor.authorLoza Vázquez, Ana
dc.contributor.authorMarin Corral, Judith
dc.contributor.authorMartínez de la Gándara, Amalia
dc.contributor.authorMartínez Varela, Ignacio
dc.contributor.authorLópez Messa, Juan
dc.contributor.authorAlbaiceta, Guillermo M.
dc.contributor.authorNovo, Mariana Andrea
dc.contributor.authorPeñasco, Yhivian
dc.contributor.authorPozo Laderas, Juan Carlos
dc.contributor.authorRicart, Pilar
dc.contributor.authorSalvador Adell, Inmaculada
dc.contributor.authorSánchez Miralles, Angel
dc.contributor.authorSancho Chinesta, Susana
dc.contributor.authorSocias, Lorenzo
dc.contributor.authorSolé Violan, Jordi
dc.contributor.authorSuares Sipmann, Fernando
dc.contributor.authorTamayo Lomas, Luis
dc.contributor.authorTrenado, José
dc.contributor.authorBarbé Illa, Ferran
dc.date.accessioned2022-01-12T13:03:24Z
dc.date.available2022-01-12T13:03:24Z
dc.date.issued2021
dc.identifier.issn1364-8535
dc.identifier.issn1466-609x
dc.identifier.urihttp://hdl.handle.net/10459.1/72712
dc.descriptionCorrecció de l'article publicat a: https://doi.org/10.1186/s13054-021-03849-2
dc.description.abstractBackground: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation.ca_ES
dc.description.sponsorshipFinancial support was provided by the Instituto de Salud Carlos III de Madrid (COV20/00110, ISCIII), Fondo Europeo de Desarrollo Regional (FEDER), "Una manera de hacer Europa", and by the Centro de Investigación Biomedica En Red – Enfermedades Respiratorias (CIBERES). DdGC has received fnancial support from Instituto de Salud Carlos III (Miguel Servet 2020: CP20/00041), co-funded by European Social Fund (ESF)/”Investing in your future”.ca_ES
dc.language.isoengca_ES
dc.publisherBMCca_ES
dc.publisherInternational Symposium on Intensive Care and Emergency Medicine (ISICEM)ca_ES
dc.publisherCritical Care Canada Forum (CCCF)ca_ES
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1186/s13054-021-03727-xca_ES
dc.relation.ispartofCritical Care, 2021, vol. 25, núm. 331ca_ES
dc.rightscc-by (c) authors, 2021ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCOVID-19ca_ES
dc.subjectCoronavirusca_ES
dc.subjectMechanical ventilationca_ES
dc.subjectSARS-CoV-2ca_ES
dc.subjectVentilatory ratioca_ES
dc.titleThe evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patientsca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.identifier.idgrec031578
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1186/s13054-021-03727-x


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