Adequate fertilization strategies are paramount to fulfill increasing demands for food, feed and fiber while reducing environmental impacts. However, their optimization under Mediterranean no-till systems has received little attention. The objective of this work was to assess winter cereal yield and water and N use efficiencies in a rainfed semiarid Mediterranean climate under (i) a range of pre-plant fertilizers [control without N fertilizer (0 N), and the following at 75 kg N ha)by reducing the number of spikes m-2 produced, pointing out that INC resulted in water deficit during the early reproductive period of the crop. While INC is often consider a best management practice to reduce NH3 volatilization losses from broadcast fertilizer applications, the results demonstrate that in rainfed Mediterranean agroecosystems water is more limiting than the N that could be potentially lost by volatilization.