Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms

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2016-06-27
Author
Pérez Fusté, Noel
Ferrezuelo, Francisco
Garí Marsol, Eloi
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Pérez Fusté, Noel; Ferrezuelo, Francisco; Garí Marsol, Eloi; . (2016) . Cyclin D1 promotes tumor cell invasion and metastasis by cytoplasmic mechanisms. Molecular & Cellular Oncology, 2016, vol. 3, núm. 5, p. e1203471. https://doi.org/10.1080/23723556.2016.1203471.
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Abstract
Amplification of cyclin D1 is a frequent alteration in many cancers of different type and origin. We recently described a novel regulatory axis involving cyclin D1 in the regulation of tumor invasion and metastasis. Membrane-associated cyclin D1-CDK4 complexes promote activation of the small GTPase RAC1 through phosphorylation of the regulatory protein paxillin.
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http://hdl.handle.net/10459.1/72530
DOI
https://doi.org/10.1080/23723556.2016.1203471
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Molecular & Cellular Oncology, 2016, vol. 3, núm. 5, p. e1203471
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