Targeting T-type channels in cancer: what is on and what is off?
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Over the last 20 years several studies have demonstrated a pivotal role of T‐type calcium channels (TTCCs) in tumor progression. Cytotoxic effects of TTCC pharmacological blockers have been reported in vitro and in preclinical models. However, the roles of TTCCs in cancer physiology are only beginning to be understood. We discuss current evidence for the signaling pathways and cellular processes stemming from TTCC activity, mainly inferred by inverse reasoning from pharmacological block and, only a few, by gene silencing or channel activation. A thorough analysis indicates that drug‐induced cytotoxicity is partially an off‐target effect. Dissection of on/off‐target activity is paramount in order to elucidate TTCC physiological roles, and to deliver efficacious therapies suited to different cancer types and stages.
Is part ofDrug Discovery Today, 2022, vol. 27, núm. 3, p. 743-758
European research projects
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