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Particle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failure

dc.contributor.authorTeis, Albert
dc.contributor.authorCediel, G.
dc.contributor.authorAmigó, Núria
dc.contributor.authorJulve, Josep
dc.contributor.authorAranyó, J.
dc.contributor.authorAndrés‑Cordón, J.
dc.contributor.authorPuig‑Jové, C.
dc.contributor.authorCastelblanco Echavarría, Esmeralda
dc.contributor.authorGual‑Capllonch, F.
dc.contributor.authorFerrer‑Sistach, E.
dc.contributor.authorVallejo, N.
dc.contributor.authorJuncà, G.
dc.contributor.authorLópez‑Ayerbe, J.
dc.contributor.authorDe Antonio, M.
dc.contributor.authorDomingo, M.
dc.contributor.authorSantiago‑Vacas, E.
dc.contributor.authorCodina, P.
dc.contributor.authorMauricio Puente, Dídac
dc.contributor.authorLupón, J.
dc.contributor.authorAlonso, Núria
dc.contributor.authorBayes‑Genis, A.
dc.date.accessioned2021-10-26T10:09:46Z
dc.date.available2021-10-26T10:09:46Z
dc.date.issued2021
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/10459.1/72143
dc.description.abstractEvidence regarding any association of HDL-particle (HDL-P) derangements and HDL-cholesterol content with cardiovascular (CV) death in chronic heart failure (HF) is lacking. To investigate the prognostic value of HDL-P size (HDL-Sz) and the number of cholesterol molecules per HDL-P for CV death in HF patients. Outpatient chronic HF patients were enrolled. Baseline HDL-P number, subfractions and HDL-Sz were measured using 1H-NMR spectroscopy. The HDL-C/P ratio was calculated as HDL-cholesterol over HDL-P. Endpoint was CV death, with non-CV death as the competing event. 422 patients were included and followed-up during a median of 4.1 (0–8) years. CV death occurred in 120 (30.5%) patients. Mean HDL-Sz was higher in CV dead as compared with survivors (8.39 nm vs. 8.31 nm, p < 0.001). This change in size was due to a reduction in the percentage of small HDL-P (54.6% vs. 60% for CV-death vs. alive; p < 0.001). HDL-C/P ratio was higher in the CV-death group (51.0 vs. 48.3, p < 0.001). HDL-Sz and HDL-C/P ratio were significantly associated with CV death after multivariable regression analysis (HR 1.22 [95% CI 1.01–1.47], p = 0.041 and HR 1.04 [95% CI 1.01–1.07], p = 0.008 respectively). HDL-Sz and HDL-C/P ratio are independent predictors of CV death in chronic HF patients.ca_ES
dc.description.sponsorshipTis work was supported by Grants from Fundació La MARATÓ de TV3 (201502 and 201516 to AB-G, 201602- 30-31 to NA and JJ), Ministerio de Educación y Ciencia (SAF2014-59892 to AB-G), AdvanceCat (2014-2020 to AB-G), Ministerio de Economía y Competitividad (MINECO)—Instituto de Salud Carlos III (ISCIII) (PI17- 00232 to JJ, PI17-01362 to NA, PI15-00625 to DM, and RED2018-102799-T to JJ), and by CIBER on Cardiovascular Diseases (CIBERCV, CB16/11/00403) and CIBER for Diabetes and Associated Metabolic Diseases (CIBERDEM, CB15/00071 and CB07/08/0016) are an initiative from ISCIII, Spain with co-funding from the European Regional Development Fund (ERDF). JJ is supported by funds provided by ISCIII (Grant CPII18/00004, Miguel Servet II program).ca_ES
dc.language.isoengca_ES
dc.publisherNature Portfolioca_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1038/s41598-021-82861-6ca_ES
dc.relation.ispartofScientific Reports, 2021, vol. 11, 3141ca_ES
dc.rightscc-by (c) Teis et al., 2021ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleParticle size and cholesterol content of circulating HDL correlate with cardiovascular death in chronic heart failureca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1038/s41598-021-82861-6


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