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Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

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Issue date
2020-08-01
Author
Mota Martorell, Natàlia
Jové Font, Mariona
Pradas Barriga, Irene
Berdún Hernández, Rebeca
Sanchez, Isabel
Naudí i Farré, Alba
Garí Marsol, Eloi
Barja, Gustavo
Pamplona Gras, Reinald
Suggested citation
Mota Martorell, Natàlia; Jové Font, Mariona; Pradas Barriga, Irene; Berdún Hernández, Rebeca; Sanchez, Isabel; Naudí i Farré, Alba; ... Pamplona Gras, Reinald. (2020) . Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity. Geroscience, 2020, vol. 42, núm. 4, p. 1157-1173. https://doi.org/10.1007/s11357-020-00210-3.
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Abstract
Maximum longevity (ML) varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of ML could to converge in the mammalian target of rapamycin (mTOR) signalling pathway. The present study is a comparative approach using heart tissue from 8 mammalian species with a ML ranging from 3.5 to 46 years. Gene expression, protein content, and concentration of regulatory metabolites of the mTOR complex 1 (mTORC1) were measured using droplet digital PCR, western blot and mass spectrometry, respectively. Our results demonstrate 1) the existence of differences species-specific in gene expression and protein content of mTORC1; 2) that the achievement of a longevity phenotype requires decreased and inhibited mTORC1; 3) decreased content of mTORC1 activators in long-lived animals, and 4) independence of phylogeny relationships on these changes. Altogether, our findings support mTORC1 down-regulation to achieve a longevous phenotype.
URI
http://hdl.handle.net/10459.1/72111
DOI
https://doi.org/10.1007/s11357-020-00210-3
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Geroscience, 2020, vol. 42, núm. 4, p. 1157-1173
European research projects
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