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dc.contributor.authorHardas, Alexandros
dc.contributor.authorSuárez-Bonnet, Alejandro
dc.contributor.authorBeck, Sam
dc.contributor.authorBecker, William E.
dc.contributor.authorRamírez Rivero, Gustavo Adolfo
dc.contributor.authorPriestnall, Simon L.
dc.description.abstractCanine gastric carcinoma (CGC) affects both sexes in relatively equal proportions, with a mean age of nine years, and the highest frequency in Staffordshire bull terriers. The most common histological subtype in 149 CGC cases was the undifferentiated carcinoma. CGCs were associated with increased chronic inflammation parameters and a greater chronic inflammatory score when Helicobacter spp. were present. Understanding the molecular pathways of gastric carcinoma is challenging. All markers showed variable expression for each subtype. Expression of the cell cycle regulator 14-3-3σ was positive in undifferentiated, tubular and papillary carcinomas. This demonstrates that 14-3-3σ could serve as an immunohistochemical marker in routine diagnosis and that mucinous, papillary and signet-ring cell (SRC) carcinomas follow a 14-3-3σ independent pathway. p16, another cell cycle regulator, showed increased expression in mucinous and SRC carcinomas. Expression of the adhesion molecules E-cadherin and CD44 appear context-dependent, with switching within tumor emboli potentially playing an important role in tumor cell survival, during invasion and metastasis. Within neoplastic emboli, acinar structures lacked expression of all markers, suggesting an independent molecular pathway that requires further investigation. These findings demonstrate similarities and differences between dogs and humans, albeit further clinicopathological data and molecular analysis are required.ca_ES
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofAnimals, 2021, vol. 11, núm. 5, 1409ca_ES
dc.rightscc-by (c) Alexandros Hardas et al., 2021ca_ES
dc.subjectGastric carcinomaca_ES
dc.subjectHelicobacter sppca_ES
dc.subjectE-cadherin and CD44ca_ES
dc.titleCanine Gastric Carcinomas: A Histopathological and Immunohistochemical Study and Similarities with the Human Counterpartca_ES

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cc-by (c) Alexandros Hardas et al., 2021
Except where otherwise noted, this item's license is described as cc-by (c) Alexandros Hardas et al., 2021