Phenolic-Rich Extracts from Avocado Fruit Residues as Functional Food Ingredients with Antioxidant and Antiproliferative Properties

Ver/ Abrir
Fecha de publicación
2021Autor/a
Velderrain Rodríguez, Gustavo R.
Quero, Javier
Osada, Jesús
Rodríguez Yoldi, María Jesús
Cita recomendada
Velderrain Rodríguez, Gustavo R.;
Quero, Javier;
Osada, Jesús;
Martín Belloso, Olga;
Rodríguez Yoldi, María Jesús;
.
(2021)
.
Phenolic-Rich Extracts from Avocado Fruit Residues as Functional Food Ingredients with Antioxidant and Antiproliferative Properties.
Biomolecules, 2021, vol.11, núm. 7, 977.
https://doi.org/10.3390/biom11070977.
Metadatos
Mostrar el registro completo del ítemResumen
In this study, the total phenolic compounds content and profile, the nutritional value, the antioxidant and antiproliferative activities of avocado peel, seed coat, and seed extracts were characterized. Additionally, an in-silico analysis was performed to identify the phenolic compounds with the highest intestinal absorption and Caco-2 permeability. The avocado peel extract possessed the highest content of phenolic compounds (309.95 ± 25.33 mMol GA/100 g of extract) and the lowest effective concentration (EC50) against DPPH and ABTS radicals (72.64 ± 10.70 and 181.68 ± 18.47, respectively). On the other hand, the peel and seed coat extracts had the lowest energy densities (226.06 ± 0.06 kcal/100 g and 219.62 ± 0.49 kcal/100 g, respectively). Regarding the antiproliferative activity, the avocado peel extract (180 ± 40 µg/mL) showed the lowest inhibitory concentration (IC50), followed by the seed (200 ± 21 µg/mL) and seed coat (340 ± 32 µg/mL) extracts. The IC50 of the extracts induced apoptosis in Caco-2 cells at the early and late stages. According to the in-silico analysis, these results could be related to the higher Caco-2 permeability to hydroxysalidroside, salidroside, sakuranetin, and luteolin. Therefore, this study provides new insights regarding the potential use of these extracts as functional ingredients with antioxidant and antiproliferative properties and as medicinal agents in diseases related to oxidative stress such as cancer.
Es parte de
Biomolecules, 2021, vol.11, núm. 7, 977Proyectos de investigación europeos
El ítem tiene asociados los siguientes ficheros de licencia: