Contributions of the international plant science community to the fight against infectious diseases in humans - part 1: epidemic and pandemic diseases, including HIV/AIDS and coronaviruses
Blanco Perera, Aamaya
Abreu, Isabel Alexandra
Buyel, Johannes F.
Cunha, Nicolau B. da
Sathish Kumar, Ramalingam
Lomonossoff, George P.
Luís, Ines M.
Ma, Julian K-C
McDonald, Karen A.
Paul, Mathew J.
Rodrigues, Julio C. M.
Shah, Priya S.
Twyman, Richard M.
Varghese, Inchakalody P.
Vianna, Giovanni R.
Wilbers, Ruud H. P.
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Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects. Such diseases cause 17% of all human deaths and their management and control places an immense burden on healthcare systems worldwide. Traditional approaches for the prevention and control of infectious diseases include vaccination programmes, hygiene measures and drugs that suppress the pathogen, treat the disease symptoms or attenuate aggressive reactions of the host immune system. The provision of vaccines and biologic drugs such as antibodies is hampered by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, particularly in developing countries where infectious diseases are prevalent and poorly controlled. Molecular farming, which uses plants for protein expression, is a promising strategy to address the drawbacks of current manufacturing platforms. In this review article, we consider the potential of molecular farming to address healthcare demands for the most prevalent and important epidemic and pandemic diseases, focussing on recent outbreaks of high-mortality coronavirus infections and diseases that disproportionately affect the developing world.
Is part ofPlant Biotechnology Journal, 2021, vol. 19, p. 1901-1920
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Except where otherwise noted, this item's license is described as cc-by (c) Lobato, Maria et al., 2021
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Contributions of the international plant science community to the fight against infectious diseases in humans - part 2: endemic and re-emerging diseases He, Wenshu; Baysal, Can; Lobato, Maria; Huang, Xin; Alvarez, Derry; Zhu, Changfu; Armario-Najera, Victoria; Blanco Perera, Aamaya; Cerda, Pedro; Saba-Mayoral, Andrea; Sobrino-Mengual, Guillermo; Vargheese, Ashwin; Abranches, Rita; Abreu, Isabel Alexandra; Balamurugan, Shanmugaraj; Bock, Ralph; Buyel, Johannes F.; Cunha, Nicolau B. da; Daniell, Henry; Faller, Roland; Folgado, André; Gowtham, Iyappan; Häkkinen, Suvi; Kumar, Shashi; Sathish Kumar, Ramalingam; Lacorte, Cristiano; Lomonossoff, George P.; Luís, Ines M.; Ma, Julian K-C; McDonald, Karen A.; Murad, Andre; Nandi, Somen; O'Keef, Barry; Parthiban, Subramanian; Paul, Mathew J.; Ponndorf, Daniel; Rech, Elibio; Rodrigues, Julio C. M.; Ruf, Stephanie; Schillberg, Stefan; Schwestka, Jennifer; Shah, Priya S.; Singh, Rahul; Stoger, Eva; Twyman, Richard M.; Varghese, Inchakalody P.; Vianna, Giovanni R.; Webster, Gina; Wilbers, Ruud H. P.; Christou, Paul; Oksman-Caldentey, Kirsi-Marja; Capell Capell, Teresa (Wiley, 2021-04-06)The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by ...
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