ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status

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2021Author
Barés Junqué, Gisel
Beà Tàrrega, Aida
Hernández, Luís
Navaridas Fernández de Bobadilla, Raúl
Felip, Isidre
Megino-Luque, Cristina
Blasco Angulo, Natividad
Nadeu, Ferran
Campo, Elías
Suggested citation
Barés Junqué, Gisel;
Beà Tàrrega, Aida;
Hernández, Luís;
Navaridas Fernández de Bobadilla, Raúl;
Felip, Isidre;
Megino-Luque, Cristina;
...
Sanchis, Daniel.
(2021)
.
ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status.
Cancers, 2021, vol. 13, núm. 15, 3803.
https://doi.org/10.3390/cancers13153803.
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Show full item recordAbstract
EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different
tumor models. Noteworthy, ENDOG deficiency reduced proliferation of endometrial tumor cells
expressing low PTEN/high p-AKT levels, and Endog deletion blunted the growth of PTEN-deficient
3D endometrial cultures. Furthermore, ENDOG silencing reduced proliferation of follicular thyroid
carcinoma and glioblastoma cell lines with high p-AKT expression. High ENDOG expression was
associated with a short time to treatment in a cohort of patients with chronic lymphocytic leukemia
(CLL), a B-cell lymphoid neoplasm with activation of PI3K/AKT. This clinical impact was observed
in the less aggressive CLL subtype with mutated IGHV in which high ENDOG and low PTEN levels
were associated with worse outcome. In summary, our results show that reducing ENDOG expression
hinders growth of some tumors characterized by low PTEN activity and high p-AKT expression and
that ENDOG has prognostic value for some cancer types.
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Cancers, 2021, vol. 13, núm. 15, 3803European research projects
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