ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status

Barés Junqué, Gisel; Beà Tàrrega, Aida; Hernández, Luís; Navaridas Fernández de Bobadilla, Raúl; Felip, Isidre; Megino-Luque, Cristina; Blasco Angulo, Natividad; Nadeu, Ferran; Campo, Elías; Llovera i Tomàs, Marta; Dolcet Roca, Xavier; Sanchis, Daniel

doi:https://doi.org/10.3390/cancers13153803

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Issue date

2021

Author

Barés Junqué, Gisel

Beà Tàrrega, Aida

Hernández, Luís

Navaridas Fernández de Bobadilla, Raúl

Felip, Isidre

Megino-Luque, Cristina

Blasco Angulo, Natividad

Nadeu, Ferran

Campo, Elías

Llovera i Tomàs, Marta

Dolcet Roca, Xavier

Sanchis, Daniel

Suggested citation

Barés Junqué, Gisel; Beà Tàrrega, Aida; Hernández, Luís; Navaridas Fernández de Bobadilla, Raúl; Felip, Isidre; Megino-Luque, Cristina; ... Sanchis, Daniel. (2021) . ENDOG Impacts on Tumor Cell Proliferation and Tumor Prognosis in the Context of PI3K/PTEN Pathway Status. Cancers, 2021, vol. 13, núm. 15, 3803. https://doi.org/10.3390/cancers13153803.

Abstract

EndoG influences mitochondrial DNA replication and is involved in somatic cell proliferation. Here, we investigated the effect of ENDOG/Endog expression on proliferation in different tumor models. Noteworthy, ENDOG deficiency reduced proliferation of endometrial tumor cells expressing low PTEN/high p-AKT levels, and Endog deletion blunted the growth of PTEN-deficient 3D endometrial cultures. Furthermore, ENDOG silencing reduced proliferation of follicular thyroid carcinoma and glioblastoma cell lines with high p-AKT expression. High ENDOG expression was associated with a short time to treatment in a cohort of patients with chronic lymphocytic leukemia (CLL), a B-cell lymphoid neoplasm with activation of PI3K/AKT. This clinical impact was observed in the less aggressive CLL subtype with mutated IGHV in which high ENDOG and low PTEN levels were associated with worse outcome. In summary, our results show that reducing ENDOG expression hinders growth of some tumors characterized by low PTEN activity and high p-AKT expression and that ENDOG has prognostic value for some cancer types.

URI

http://hdl.handle.net/10459.1/71796

DOI

https://doi.org/10.3390/cancers13153803

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Cancers, 2021, vol. 13, núm. 15, 3803

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Except where otherwise noted, this item's license is described as cc-by (c) Barés et al., 2021