A toxicokinetic study reflecting the absorption, distribution, metabolism and excretion of deoxynivalenol in broiler chickens

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2021-01Suggested citation
Riahi, Insaf;
Ramos Girona, Antonio J.;
Pérez-Vendrell, Anna Maria;
Marquis, Virginie;
.
(2021)
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A toxicokinetic study reflecting the absorption, distribution, metabolism and excretion of deoxynivalenol in broiler chickens.
Journal of applied animal research, 2021, vol. 49, núm. 1, p. 284-288.
https://doi.org/10.1080/09712119.2021.1946403.
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To identify the specific biomarkers of exposure of DON in chickens, a toxicokinetic study was performed
via oral or intravenous application of deoxynivalenol (DON). Doses of 0.75 and 2.25 mg DON/kg of body
weight (BW) were administrated intravenously or orally to the chickens. Next, blood samples were
collected at several time points and plasma was obtained. Liquid chromatography–tandem massspectrometry (LC–MS/MS) was used to quantify plasma levels of DON and its metabolite DON-3-
sulphate (DON-3S). A non-compartmental analysis was performed to study the main toxicokinetic
parameters after intravenous or oral application of the toxin. Regarding oral administration, DON
plasma level was below the limit of detection (LOD) of the method (1.5 ng/mL) and DON-3S could not
be identified. After intravenous administration of DON at 0.75 and 2.25 mg DON/kg BW, the
elimination half-life was 57.1 and 47.7 min, respectively, indicating the rapid elimination of DON. The
metabolite DON-3S was found in plasma of broilers exposed to DON intravenously. The absence of
DON in chicken plasma after oral bolus application suggests the low absorption of this mycotoxin.
The presence of DON-3S in plasma indicates that this metabolite could be the appropriate biomarker
of DON exposure in chickens.
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Journal of applied animal research, 2021, vol. 49, núm. 1, p. 284-288European research projects
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