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dc.contributor.authorCompanys, Judit
dc.contributor.authorGosalbes, Maria José
dc.contributor.authorPla-Paga, Laura
dc.contributor.authorCalderon-Perez, Lorena
dc.contributor.authorLlaurado, Elisabet
dc.contributor.authorPedret, Anna
dc.contributor.authorValls, Rosa Maria
dc.contributor.authorJiménez-Hernández, Núria
dc.contributor.authorSandoval-Ramírez, Berner Andrée
dc.contributor.authordel Bas, Josep Maria
dc.contributor.authorCaimari, Antoni
dc.contributor.authorRubió Piqué, Laura
dc.contributor.authorSolà, Rosa
dc.description.abstractWe aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.ca_ES
dc.description.sponsorshipThis research was funded by the Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation, grant number CER-20191010.
dc.relation.isformatofReproducció del document publicat a
dc.relation.ispartofNutrients, 2021, vol. 13, núm. 6, p. 1-17ca_ES
dc.rightscc-by (c) Companys et al., 2021ca_ES
dc.subject.otherÀcids grassos saturatsca_ES
dc.titleGut microbiota profile and its association with clinical variables and dietary intake in overweight/obese and lean subjects: A cross-sectional studyca_ES

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