Gut microbiota profile and its association with clinical variables and dietary intake in overweight/obese and lean subjects: A cross-sectional study

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2021-06
Author
Companys, Judit
Gosalbes, Maria Jose
Pla-Paga, Laura
Calderon-Perez, Lorena
Llaurado, Elisabet
Pedret, Anna
Valls, Rosa Maria
Jiménez-Hernández, Núria
Sandoval-Ramírez, Berner Andree
del Bas, Josep Maria
Caimari, Antoni
Rubió Piqué, Laura
Solà, Rosa
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Companys, Judit; Gosalbes, Maria Jose; Pla-Paga, Laura; Calderon-Perez, Lorena; Llaurado, Elisabet; Pedret, Anna; ... Solà, Rosa. (2021) . Gut microbiota profile and its association with clinical variables and dietary intake in overweight/obese and lean subjects: A cross-sectional study. Nutrients, 2021, vol. 13, núm. 6, p. 1-17. https://doi.org/10.3390/nu13062032.
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Abstract
We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.
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http://hdl.handle.net/10459.1/71696
DOI
https://doi.org/10.3390/nu13062032
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Nutrients, 2021, vol. 13, núm. 6, p. 1-17
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cc-by (c) Companys et al., 2021
Except where otherwise noted, this item's license is described as cc-by (c) Companys et al., 2021