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dc.contributor.authorBlanco Fuertes, Miguel
dc.contributor.authorCorrea Fiz, Florencia
dc.contributor.authorFraile Sauce, Lorenzo José
dc.contributor.authorSibila, Marina
dc.contributor.authorAragon, Virginia
dc.date.accessioned2021-07-19T08:11:26Z
dc.date.available2021-07-19T08:11:26Z
dc.date.issued2021
dc.identifier.issn2076-0817
dc.identifier.urihttp://hdl.handle.net/10459.1/71672
dc.description.abstractFibrinous polyserositis in swine farming is a common pathological finding in nursery animals. The differential diagnosis of this finding should include Glaesserella parasuis (aetiological agent of Glässer's disease) and Mycoplasma hyorhinis, among others. These microorganisms are early colonizers of the upper respiratory tract of piglets. The composition of the nasal microbiota at weaning was shown to constitute a predisposing factor for the development of Glässer's disease. Here, we unravel the role of the nasal microbiota in the subsequent systemic infection by M. hyorhinis, and the similarities and differences with Glässer's disease. Nasal samples from farms with recurrent problems with polyserositis associated with M. hyorhinis (MH) or Glässer's disease (GD) were included in this study, together with healthy control farms (HC). Nasal swabs were taken from piglets in MH farms at weaning, before the onset of the clinical outbreaks, and were submitted to 16S rRNA gene amplicon sequencing (V3-V4 region). These sequences were analyzed together with sequences from similar samples previously obtained in GD and HC farms. Animals from farms with disease (MH and GD) had a nasal microbiota with lower diversity than those from the HC farms. However, the composition of the nasal microbiota of the piglets from these disease farms was different, suggesting that divergent microbiota imbalances may predispose the animals to the two systemic infections. We also found variants of the pathogens that were associated with the farms with the corresponding disease, highlighting the importance of studying the microbiome at strain-level resolution
dc.description.sponsorshipThis research was funded by the Ministry of Economy and Competitiveness (MINECO) of the Spanish Government (grant number AGL2016-77361). MBF is a recipient of an FPI fellowship, also from MINECO (Spain). The authors are also grateful to the Centres de Recerca de Catalunya (CERCA) Programme.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherMDPI
dc.relationMINECO/PN2013-2016/AGL2016-77361
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.3390/pathogens10050603
dc.relation.ispartofPathogens, 2021, vol. 10, num. 603, p. 1-11
dc.rightscc-by (c) Blanco Fuertes, Miguel et al., 2021
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.classificationMicrobiota
dc.subject.classificationFossa nasal
dc.subject.classificationGlässer’s disease
dc.subject.classification16S rRNA gene
dc.subject.otherMycoplasma hyorhinis
dc.subject.otherPorcs
dc.titleChanges in nasal microbiota composition associated with development of polyserositis by Mycoplasma hyorhinis
dc.typeinfo:eu-repo/semantics/article
dc.date.updated2021-07-19T08:11:26Z
dc.identifier.idgrec031301
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.identifier.doihttps://doi.org/10.3390/pathogens10050603


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cc-by (c) Blanco Fuertes, Miguel et al., 2021
Except where otherwise noted, this item's license is described as cc-by (c) Blanco Fuertes, Miguel et al., 2021