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dc.contributor.authorGonzalez Sanmartín, Román
dc.contributor.authorElvira Partida, Laura
dc.contributor.authorCarbonell Baeza, Carlos
dc.contributor.authorVertenten, Geert
dc.contributor.authorFraile Sauce, Lorenzo José
dc.description.abstractNeonatal calf diarrhoea (NCD) is a major health challenge with a negative impact on farm profitability, calf welfare and antimicrobial use. Neonatal calves are particularly sensitive to enteric infections. Thus, a key point for prevention is minimising infectious pressure and maximising specific immune responses. An amount of 120 dams not previously vaccinated against NCD were randomly allocated to one of three study groups: negative control versus two vaccinated groups (A and B). In the control group, the average level of antibodies was significantly low for both BoCV and ETEC (15.6 and 13.9% in the colostrum samples, respectively), demonstrating the importance of dam vaccination. Indeed, the level of specific immunity was significantly increased for BoCV and ETEC with dam vaccination using both one-shot vaccines versus the control group. Moreover, the statistical analysis revealed a significantly higher level of antibodies for BoCV and ETEC in colostrum samples in vaccine A versus vaccine B and the control group. In accordance, the calf serum demonstrated a significantly higher level and greater homogeneity of antibodies against BoCV and ETEC in the Vaccine A group versus other experimental groups (p < 0.05). In conclusion, this study demonstrated a different specific immune response for the pathogens depending on the vaccine used to control NCD in cows.
dc.description.sponsorshipThis research was funded by MSD Animal Health, PC17-LE01-02.
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofAnimals, 2021, vol. 11, num. 5, p. 1238
dc.rightscc-by (c) Gonzalez Sanmartín et al., 2021
dc.subjectImmune response
dc.subjectNeonatal diarrhoea
dc.subjectPassive immunity
dc.titleThe Specific Immune Response after Vaccination against Neonatal Calf Diarrhoea Differs between Apparent Similar Vaccines in a Case Study

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cc-by (c) Gonzalez Sanmartín et al., 2021
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