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dc.contributor.authorYuste, Silvia
dc.contributor.authorLudwig, Iziar A.
dc.contributor.authorRomero Fabregat, Mª Paz
dc.contributor.authorPiñol Felis, Carme
dc.contributor.authorCatalán Santos, Úrsula
dc.contributor.authorPedret, Anna
dc.contributor.authorValls, Rosa M.
dc.contributor.authorFernández Castillejo, Sara
dc.contributor.authorMotilva Casado, Mª José
dc.contributor.authorMacià i Puig, Ma Alba
dc.contributor.authorRubió Piqué, Laura
dc.date.accessioned2021-04-21T11:09:04Z
dc.date.issued2021
dc.identifier.issn1613-4125
dc.identifier.issn1613-4133
dc.identifier.urihttp://hdl.handle.net/10459.1/71100
dc.description.abstractThe present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high‐fat diet (HFD) to induce hypercholesterolemia and supplemented with red‐fleshed apple (HFD+R), white‐fleshed apple (HFD+W) or an ACN‐rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis and phenol biological metabolites were determined. Plasma, urine and faeces showed a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan‐3‐ols were significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect was observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function was improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) was also observed. Our findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan‐3‐ols, together with dihydrochalcones, compose a phenolic phytocomplex in red and white‐fleshed apples, respectively, that could act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.ca_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Industry, Economy and Competitiveness through the AGL2016-76943-C2-1-R and AGL2016-76943-C2-2-R projects (co-funded by the European Social Fund, European Union). I.A.L. enjoys a post-doctoral contract (2017PMF-POST2-19) from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV). S.Y. was supported by a grant from the University of Lleida. Ú.C. has a Pla estratègic de recerca i innovació en salut (PERIS) post-doctoral grant (SLT002/16/00239; Catalunya, Spain) from Generalitat de Catalunya. A.P. enjoys a post-doctoral grant (PTQ-15-08068; Spain). In addition, the authors are grateful to NUFRI SAT (Mollerussa, Lleida, Catalonia, Spain) for providing the red-fleshed apples. We are grateful to A. Martínez (Department of Medicine, University of Lleida) for helpful with the histological stains. Finally, we are grateful to SCT-Estabulari of the University of Lleida where the animal experiment was carried out.ca_ES
dc.language.isoengca_ES
dc.publisherWileyca_ES
dc.relationMINECO/PN2013-2016/AGL2016-76943-C2-1-Rca_ES
dc.relationMINECO/PN2013-2016/AGL2016-76943-C2-2-Rca_ES
dc.relation.isformatofVersió postprint del document publicat a https://doi.org/10.1002/mnfr.202001225ca_ES
dc.relation.ispartofMolecular Nutrition & Food Research, 2021. In Pressca_ES
dc.rights(c) Wiley, 2021ca_ES
dc.subjectAnthocyaninsca_ES
dc.subjectAortic thicknessca_ES
dc.subjectBowman's spaceca_ES
dc.subjectPhenolic compoundsca_ES
dc.subjectRed-fleshed appleca_ES
dc.subjectSustained intakeca_ES
dc.subjectUPLC-MS/MSca_ES
dc.titleMetabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Studyca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccessca_ES
dc.identifier.doihttps://doi.org/10.1002/mnfr.202001225
dc.date.embargoEndDate2022-04-14


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