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Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study

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Issue date
2021
Author
Yuste, Silvia
Ludwig, Iziar A.
Romero Fabregat, Mª Paz
Piñol Felis, Carme
Catalán Santos, Úrsula
Pedret, Anna
Valls, Rosa M.
Fernández Castillejo, Sara
Motilva Casado, Mª José
Macià i Puig, Ma Alba
Rubió Piqué, Laura
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Yuste, Silvia; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Piñol Felis, Carme; Catalán Santos, Úrsula; Pedret, Anna; ... Rubió Piqué, Laura. (2021) . Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study. Molecular Nutrition & Food Research, 2021, vol. 65, núm. 10, p. 2001225. https://doi.org/10.1002/mnfr.202001225.
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Abstract
The present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high‐fat diet (HFD) to induce hypercholesterolemia and supplemented with red‐fleshed apple (HFD+R), white‐fleshed apple (HFD+W) or an ACN‐rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis and phenol biological metabolites were determined. Plasma, urine and faeces showed a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan‐3‐ols were significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect was observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function was improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) was also observed. Our findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan‐3‐ols, together with dihydrochalcones, compose a phenolic phytocomplex in red and white‐fleshed apples, respectively, that could act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.
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http://hdl.handle.net/10459.1/71100
DOI
https://doi.org/10.1002/mnfr.202001225
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Molecular Nutrition & Food Research, 2021, vol. 65, núm. 10, p. 2001225
European research projects
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