Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study

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2021
Author
Yuste, Silvia
Ludwig, Iziar A.
Romero Fabregat, Mª Paz
Piñol Felis, Carme
Catalán Santos, Úrsula
Pedret, Anna
Valls, Rosa M.
Fernández Castillejo, Sara
Motilva Casado, Mª José
Macià i Puig, Ma Alba
Rubió Piqué, Laura
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Yuste, Silvia; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Piñol Felis, Carme; Catalán Santos, Úrsula; Pedret, Anna; ... Rubió Piqué, Laura. (2021) . Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study. Molecular Nutrition & Food Research, 2021. In Press. https://doi.org/10.1002/mnfr.202001225.
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Abstract
The present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high‐fat diet (HFD) to induce hypercholesterolemia and supplemented with red‐fleshed apple (HFD+R), white‐fleshed apple (HFD+W) or an ACN‐rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis and phenol biological metabolites were determined. Plasma, urine and faeces showed a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan‐3‐ols were significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect was observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function was improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) was also observed. Our findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan‐3‐ols, together with dihydrochalcones, compose a phenolic phytocomplex in red and white‐fleshed apples, respectively, that could act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.
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http://hdl.handle.net/10459.1/71100
DOI
https://doi.org/10.1002/mnfr.202001225
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Molecular Nutrition & Food Research, 2021. In Press
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