Metabolic fate and cardiometabolic effects of phenolic compounds from red‐fleshed apple in hypercholesterolemic rats: A comparative study with common white‐fleshed apple. The AppleCOR Study
Ludwig, Iziar A.
Catalán Santos, Úrsula
Valls, Rosa M.
Fernández Castillejo, Sara
MetadataShow full item record
The present study aimed to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds (PC) provided by a red‐fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats were feed with high‐fat diet (HFD) to induce hypercholesterolemia and supplemented with red‐fleshed apple (HFD+R), white‐fleshed apple (HFD+W) or an ACN‐rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis and phenol biological metabolites were determined. Plasma, urine and faeces showed a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan‐3‐ols were significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect was observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function was improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) was also observed. Our findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan‐3‐ols, together with dihydrochalcones, compose a phenolic phytocomplex in red and white‐fleshed apples, respectively, that could act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.
Is part ofMolecular Nutrition & Food Research, 2021, vol. 65, núm. 10, p. 2001225
European research projects
Showing items related by title, author, creator and subject.
Validation of dried blood spot cards to determine apple phenolic metabolites in human blood and plasma after an acute intake of red-fleshed apple snack Yuste, Silvia; Macià i Puig, Ma Alba; Ludwig, Iziar A.; Romero Fabregat, Mª Paz; Fernández Castillejo, Sara; Catalán Santos, Úrsula; Motilva Casado, Mª José; Rubió Piqué, Laura (Wiley, 2018)Scope: The application of dried blood spot (DBS) cards for the study in human blood of dietary polyphenol bioavailability has been poorly studied. Methods and results: An analytical method based on blood sampling with DBS ...
In vivo biotransformation of (poly)phenols and anthocyanins of red-fleshed apple and identification of intake biomarkers Yuste, Silvia; Ludwig, Iziar A.; Rubió Piqué, Laura; Romero Fabregat, Mª Paz; Pedret, Anna; Valls, Rosa M.; Solà, Rosa; Motilva Casado, Mª José; Macià i Puig, Ma Alba (Elsevier, 2019)The aim of this study was to investigate comprehensively the metabolic pathways and human bioavailability of anthocyanins and other phenolic compounds in apple matrix, and to elucidate potential intake biomarkers. After ...
Thermal and non-thermal processing of red-fleshed apple: how are (poly)phenol composition and bioavailability affected? Yuste, Silvia; Macià i Puig, Ma Alba; Motilva Casado, Mª José; Prieto Diez, Neus; Romero Fabregat, Mª Paz; Pedret, Anna; Solà, Rosa; Ludwig, Iziar A.; Rubió Piqué, Laura (The Royal Society of Chemistry, 2020)The present study evaluated the impact of different thermal (infrared-drying, hot air-drying and purée pas-teurization) and non-thermal (freeze-drying) processing technologies on red-fleshed apple (poly)phenoliccompounds. ...