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dc.contributor.authorPrieto Ramos, Jorge
dc.contributor.authorCorda, Andrea
dc.contributor.authorSwift, Simon
dc.contributor.authorSaderi, Laura
dc.contributor.authorde la Fuente Oliver, Gabriel
dc.contributor.authorCorcoran, Brendan
dc.contributor.authorSummers, Kim M.
dc.contributor.authorFrench, Anne T.
dc.description.abstractMyxomatous mitral valve disease (MMVD) is the most common cardiac disease in dogs. It varies from dogs without clinical signs to those developing left-sided congestive heart failure, leading to death. Cavalier King Charles Spaniels (CKCSs) are particularly susceptible to MMVD. We hypothesised that within the elderly CKCS population, there is a sub-cohort of MMVD-affected dogs that do not have cardiac remodelling. The objectives of the present study were (i) to determine the prevalence and the degree of cardiac remodelling associated with MMVD; and (ii) assess the effect of age, gender, and body weight on echocardiographic status in a population of aged CKCSs. A total of 126 CKCSs ≥ 8 years old were prospectively included. They all had a physical and echocardiographic examination. A systolic murmur was detected in 89% of dogs; the presence of clinical signs was reported in 19% of them; and echocardiographic evidence of MMVD was described in 100%. Despite the high prevalence, 44.4% of the dogs were clear of echocardiographic signs of cardiac remodelling. Age was significantly associated with the presence and severity of cardiac remodelling and mitral valve prolapse. Our results showed that a proportion of elderly CKCS with confirmed MMVD did not undergo advanced stages of this pathology.ca_ES
dc.description.sponsorshipThis research was funded by the British CKCS Breed Club and The Roslin Institute, University of Edinburgh.ca_ES
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofAnimals, 2021, vol. 11, núm. 4, p. 949ca_ES
dc.rightscc-by (c) Prieto Ramos et al., 2021ca_ES
dc.subjectMyxomatous mitral valve diseaseca_ES
dc.subjectMitral valve degenerationca_ES
dc.subjectMitral valve prolapseca_ES
dc.subjectCardiac remodellingca_ES
dc.subjectCavalier King Charles Spanielca_ES
dc.titleClinical and Echocardiographic Findings in an Aged Population of Cavalier King Charles Spanielsca_ES

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cc-by (c) Prieto Ramos et al., 2021
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