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dc.contributor.authorGarcía-Casas, Ana
dc.contributor.authorGarcía-Olmo, Dolores C.
dc.contributor.authorGarcía-Olmo, Damián
dc.identifier.citationWorld Journal of Clinical Oncology, 2017, vol. 8, núm. 5, p. 378-388ca_ES
dc.description.abstractMetastasis is the major cause of mortality in cancer disease and still constitutes one of the most controversial mechanism, not yet fully understood. What is almost beyond doubt is that circulatory system is crucial for cancer propagation. Regarding this system, much attention has been recently paid to liquid biopsy. This technique is aimed to detect circulating tumor cells (CTCs) and circulating nucleic acids so it can be used as a tool for diagnostic, prognostic and follow-up of patients. Whereas CTCs tend to be scarce in serum and plasma from cancer patient, abundant circulating nucleic acids can be detected in the same location. This fact, together with the genetic origin of cancer, stands out the relevance of circulating nucleic acids and shed light into the role of nucleic acids as drivers of metastasis, a recently discovered phenomenon called Genometastasis. This innovative theory supports the transfer of oncogenes from cancer cells to normal and susceptible cells located in distant target organs through circulatory system. What is more, many biological processes haven been described to deliver and secrete circulating nucleic acids into the circulation which can allow such horizontal transfer of oncogenes. In this review, we focus not only on these mechanisms but also we demonstrate its putative role in cancer propagation and give insights about possible therapeutic strategies based on this theory. Our objective is to demonstrate how findings about cell-to-cell communications and previous results can agree with this unprecedented theory.ca_ES
dc.publisherBaishideng Publishing Groupca_ES
dc.relation.isformatofReproducció del document publicat a
dc.rightscc-by-nc (c) García-Casas et al., 2017ca_ES
dc.subjectCancer metastasisca_ES
dc.subjectCirculating Nucleic acidsca_ES
dc.subjectCirculating tumor cellsca_ES
dc.subjectLiquid biopsyca_ES
dc.titleFurther the liquid biopsy: Gathering pieces of the puzzle of genometastasis theoryca_ES

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cc-by-nc (c) García-Casas et al., 2017
Except where otherwise noted, this item's license is described as cc-by-nc (c) García-Casas et al., 2017