Further the liquid biopsy: Gathering pieces of the puzzle of genometastasis theory
García-Olmo, Dolores C.
MetadataShow full item record
Metastasis is the major cause of mortality in cancer disease and still constitutes one of the most controversial mechanism, not yet fully understood. What is almost beyond doubt is that circulatory system is crucial for cancer propagation. Regarding this system, much attention has been recently paid to liquid biopsy. This technique is aimed to detect circulating tumor cells (CTCs) and circulating nucleic acids so it can be used as a tool for diagnostic, prognostic and follow-up of patients. Whereas CTCs tend to be scarce in serum and plasma from cancer patient, abundant circulating nucleic acids can be detected in the same location. This fact, together with the genetic origin of cancer, stands out the relevance of circulating nucleic acids and shed light into the role of nucleic acids as drivers of metastasis, a recently discovered phenomenon called Genometastasis. This innovative theory supports the transfer of oncogenes from cancer cells to normal and susceptible cells located in distant target organs through circulatory system. What is more, many biological processes haven been described to deliver and secrete circulating nucleic acids into the circulation which can allow such horizontal transfer of oncogenes. In this review, we focus not only on these mechanisms but also we demonstrate its putative role in cancer propagation and give insights about possible therapeutic strategies based on this theory. Our objective is to demonstrate how findings about cell-to-cell communications and previous results can agree with this unprecedented theory.
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by-nc (c) García-Casas et al., 2017
Showing items related by title, author, creator and subject.
Liquid biopsy by NGS: differential presence of exons (DPE) in cell-free DNA reveals different patterns in metastatic and nonmetastatic colorectal cancer Olmedillas-López, Susana; García-Olmo, Dolores C.; García-Arranz, Mariano; Peiró-Pastor, Ramón; Aguado, Begoña; García-Olmo, Damián (Wiley Open Access, 2018)Next-generation sequencing (NGS) has been proposed as a suitable tool for liquid biopsy in colorectal cancer (CRC), although most studies to date have focused almost exclusively on sequencing of panels of potential clinically ...
The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer Shelton, Phillip M.; Duran, Angeles; Nakanishi, Yuki; Reina-Campos, Miguel; Kasashima, Hiroaki; Llado, Victoria; Ma, Li; Campos, Alex; García-Olmo, Damián; García-Arranz, Mariano; García-Olmo, Dolores C.; Olmedillas-López, Susana; Caceres, Javier F.; Diaz-Meco, Maria T.; Moscat, Jorge (Elsevier, 2018)Most colorectal cancer (CRC)-related deaths are due to liver metastases. PKCζ is a tumor suppressor in CRC with reduced expression in metastasis. Given the importance of microRNAs (miRNAs) in regulating cellular plasticity, ...
Mantilla-Escalante, Diana C.; López de las Hazas Mingo, María del Carmen; Gil-Zamorano, Judit; Pozo-Acebo, Lorena del; Crespo, M. Carmen; Martín-Hernández, Roberto; Saz, Andrea del; Tomé-Carneiro, Joao; Cardona, Fernando; Cornejo-Pareja, Isabel; García-Ruiz, Almudena; Briand, Olivier; Lasunción Ripa, Miguel Ángel; Visioli, F. (Francesco); Dávalos, Alberto (MDPI, 2019-06-13)Postprandial lipemia has many physiopathological effects, some of which increase the risk of cardiovascular disease. MicroRNAs (miRNAs) can be found in almost all biological fluids, but their postprandial kinetics are ...