A salmon peptide diet alleviates experimental colitis as compared with fish oil
Cacabelos Barral, Daniel
Aasprong, Ole G.
Berge, Rolf K.
MetadataShow full item record
Fish oil (FO) has been shown to have anti-inflammatory properties in animal models of inflammatory bowel disease, but how fish peptides (FP) influence intestinal inflammation has been less studied. Male Wistar rats, divided into five groups, were included in a 4-week dietary intervention study. Of the groups, four were exposed in the fourth week to 5 % dextran sulfate sodium (DSS) to induce colitis, while one group was unexposed. The diets were: (1) control, (2) control + DSS, (3) FO (5 %) + DSS, (4) FP (3·5 %) + DSS, (5) FO + FP + DSS. Following DSS intake, weight and disease activity index (DAI) were assessed, and histological combined score (HCS), selected colonic PG, cytokines, oxidative damage markers and mRNA levels were measured. FP reduced HCS, tended to lower DAI (P = 0·07) and reduced keratinocyte chemoattractant/growth-regulated oncogene levels, as compared with the FO diet. FP also reduced mRNA levels of Il-6 and Cxcl1, although not significantly. FO intake increased the DAI as compared with DSS alone. PGE3 levels increased after the FO diet, and even more following FO + FP intake. The FP diet seems to have a protective effect in DSS-induced colitis as compared with FO. A number of beneficial, but non-significant, changes also occurred after FP v. DSS. A combined FO + FP diet may influence PG synthesis, as PGE3 levels were higher after the combined diet than after FO alone.
Is part ofJournal of Nutritional Science, 2013, vol. 2, e2
European research projects
The following license files are associated with this item:
Except where otherwise noted, this item's license is described as cc-by-nc-sa (c) Grimstad et al., 2013
Showing items related by title, author, creator and subject.
Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy López Erauskin, Jone; Galino, Jorge; Ruiz, M.; Cuezva, J. M.; Fabregat, I.; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Martínez, Juan José; Ferrer, Isidre; Pamplona Gras, Reinald; Villarroya, Francesc; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, A. (Oxford Journals, 2013)X-linked adrenoleukodystrophy (X-ALD) is an inherited metabolic disorder of the nervous system characterized by axonopathy in spinal cords and/or cerebral demyelination, adrenal insufficiency and accumulation of very ...
Plant-derived phenolics inhibit the accrual of structurally characterised protein and lipid oxidative modifications Soler Cantero, Arantza; Jové Font, Mariona; Cacabelos Barral, Daniel; Boada Pallàs, Jordi; Naudí i Farré, Alba; Romero Fabregat, Mª Paz; Cassanyé, Anna; Serrano Casasola, José Carlos Enrique; Arola i Ferrer, Lluís; Valls, Josep; Bellmunt i Curcó, Josepa; Prat Corominas, Joan; Pamplona Gras, Reinald; Portero Otín, Manuel; Motilva Casado, Mª José (Public Library of Science, 2012)Epidemiological data suggest that plant-derived phenolics beneficial effects include an inhibition of LDL oxidation. After applying a screening method based on 2,4-dinitrophenyl hydrazine- protein carbonyl reaction to 21 ...
Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction Naudí i Farré, Alba; Jové Font, Mariona; Cacabelos Barral, Daniel; Ayala Jové, Ma. Victoria (Maria Victoria); Cabré Cucó, Rosanna; Caro, Pilar; Gomez, José; Portero Otín, Manuel; Barja, Gustavo; Pamplona Gras, Reinald (Springer Verlag, 2013)Maillard reaction contributes to the chemical modification and cross-linking of proteins. This process plays a significant role in the aging process and determination of animal longevity. Oxidative conditions promote the ...