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dc.contributor.authorQuiroga, Borja
dc.contributor.authorArroyo, David
dc.contributor.authorArriba, Gabriel de
dc.date.accessioned2021-03-22T11:10:25Z
dc.date.available2021-03-22T11:10:25Z
dc.date.issued2015
dc.identifier.issn2314-6745
dc.identifier.urihttp://hdl.handle.net/10459.1/70830
dc.description.abstractDiabetic kidney disease is the leading cause of end-stage renal disease. Albuminuria is recognized as the most important prognostic factor for chronic kidney disease progression. For this reason, blockade of renin-angiotensin system remains the main recommended strategy, with either angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. However, other antiproteinuric treatments have begun to be studied, such as direct renin inhibitors or aldosterone blockers. Beyond antiproteinuric treatments, other drugs such as pentoxifylline or bardoxolone have yielded conflicting results. Finally, alternative pathogenic pathways are being explored, and emerging therapies including antifibrotic agents, endothelin receptor antagonists, or transcription factors show promising results. The aim of this review is to explain the advances in newer agents to treat diabetic kidney disease, along with the background of the renin-angiotensin system blockade.ca_ES
dc.language.isoengca_ES
dc.publisherHindawica_ES
dc.relation.isformatofReproducció del document publicat a https://doi.org/10.1155/2015/801348ca_ES
dc.relation.ispartofJournal of Diabetes Research, 2015, vol. 2015, ID. 801348ca_ES
dc.rightscc-by (c) Quiroga et al., 2015ca_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectRonyons -- Malaltiesca_ES
dc.titlePresent and Future in the Treatment of Diabetic Kidney Diseaseca_ES
dc.typeinfo:eu-repo/semantics/articleca_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_ES
dc.identifier.doihttps://doi.org/10.1155/2015/801348


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cc-by (c) Quiroga et al., 2015
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